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dc.contributor.authorOzkan A.D.en_US
dc.contributor.authorTopal, A. E.en_US
dc.contributor.authorDikecoglu, F. B.en_US
dc.contributor.authorGuler, M. O.en_US
dc.contributor.authorDana, A.en_US
dc.contributor.authorTekinay, A. B.en_US
dc.date.accessioned2018-04-12T13:45:32Z
dc.date.available2018-04-12T13:45:32Z
dc.date.issued2018en_US
dc.identifier.issn1084-9521
dc.identifier.urihttp://hdl.handle.net/11693/38139
dc.description.abstractAtomic force microscopy is an emerging tool for investigating the biomolecular aspects of cellular interactions; however, cell and tissue analyses must frequently be performed in aqueous environment, over rough surfaces, and on complex adhesive samples that complicate the imaging process and readily facilitate the blunting or fouling of the AFM probe. In addition, the shape and surface chemistry of the probe determine the quality and types of data that can be acquired from biological materials, with certain information becoming available only within a specific range of tip lengths or diameters, or through the assistance of specific chemical or biological functionalization procedures. Consequently, a broad range of probe modification techniques has been developed to extend the capabilities and overcome the limitations of biological AFM measurements, including the fabrication of AFM tips with specialized morphologies, surface coating with biologically affine molecules, and the attachment of proteins, nucleic acids and cells to AFM probes. In this review, we underline the importance of probe choice and modification for the AFM analysis of biomaterials, discuss the recent literature on the use of non-standard AFM tips in life sciences research, and consider the future utility of tip functionalization methods for the investigation of fundamental cell and tissue interactions. © 2017 Elsevier Ltden_US
dc.language.isoEnglishen_US
dc.source.titleSeminars in Cell and Developmental Biologyen_US
dc.relation.isversionofhttp://dx.doi.org/10.1016/j.semcdb.2017.08.018en_US
dc.subjectAtomic force microscopyen_US
dc.subjectBiological specimensen_US
dc.subjectProbe modificationen_US
dc.titleProbe microscopy methods and applications in imaging of biological materialsen_US
dc.typeReviewen_US
dc.departmentInstitute of Materials Science and Nanotechnology (UNAM)en_US
dc.citation.spage153en_US
dc.citation.epage164en_US
dc.citation.volumeNumber73en_US
dc.identifier.doi10.1016/j.semcdb.2017.08.018en_US
dc.publisherElsevier Ltden_US
dc.embargo.release2019-01-01en_US


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