miR-200c: a versatile watchdog in cancer progression, EMT, and drug resistance
Date
2016-06Source Title
Journal of Molecular Medicine
Print ISSN
0946-2716
Publisher
Springer Verlag
Volume
94
Issue
6
Pages
629 - 644
Language
English
Type
ReviewItem Usage Stats
267
views
views
601
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downloads
Abstract
MicroRNAs (miRNAs) are 20–22-nucleotide small endogenous non-coding RNAs which regulate gene expression at post-transcriptional level. In the last two decades, identification of almost 2600 miRNAs in human and their potential to be modulated opened a new avenue to target almost all hallmarks of cancer. miRNAs have been classified as tumor suppressors or oncogenes depending on the phenotype they induce, the targets they modulate, and the tissue where they function. miR-200c, an illustrious tumor suppressor, is one of the highly studied miRNAs in terms of development, stemness, proliferation, epithelial-mesenchymal transition (EMT), therapy resistance, and metastasis. In this review, we first focus on the regulation of miR-200c expression and its role in regulating EMT in a ZEB1/E-cadherin axis-dependent and ZEB1/E-cadherin axis-independent manner. We then describe the role of miR-200c in therapy resistance in terms of multidrug resistance, chemoresistance, targeted therapy resistance, and radiotherapy resistance in various cancer types. We highlight the importance of miR-200c at the intersection of EMT and chemoresistance. Furthermore, we show how miR-200c coordinates several important signaling cascades such as TGF-β signaling, PI3K/Akt signaling, Notch signaling, VEGF signaling, and NF-κB signaling. Finally, we discuss miR-200c as a potential prognostic/diagnostic biomarker in several diseases, but mainly focusing on cancer and its potential application in future therapeutics.
Keywords
BiomarkerCell signaling
Drug resistance
Epithelial-mesenchymal transition (EMT)
miR-200c
TGF-β
ZEB1/2
Immunoglobulin enhancer binding protein
MicroRNA 200c
Phosphatidylinositol 3 kinase
Transcription factor ZEB1
Transforming growth factor beta
Uvomorulin
Vasculotropin
Antineoplastic agent
Cadherin
CDH1 protein, human
MicroRNA
MIRN200 microRNA, human
Transcription factor ZEB1
Transforming growth factor beta
ZEB1 protein, human
ZEB2 protein, human
Zinc finger E box binding homeobox 2
Cancer growth
Cancer resistance
Chemotherapy resistance
Epithelial mesenchymal transition
Gene expression
Guard dog
Multidrug resistance
Nonhuman
Radiotherapy resistance
Review
Therapy resistance
Animal
Cell transformation
Disease exacerbation
Drug resistance
Epithelial mesenchymal transition
Gene expression regulation
Genetics
Human
Metabolism
Neoplasm
Pathology
Signal transduction
Animals
Antineoplastic Agents
Cadherins
Cell Transformation, Neoplastic
Disease Progression
Drug Resistance, Neoplasm
Epithelial-Mesenchymal Transition
Gene Expression Regulation, Neoplastic
Humans
MicroRNAs
Neoplasms
Signal Transduction
Transforming Growth Factor beta
Zinc Finger E-box Binding Homeobox 2
Zinc Finger E-box-Binding Homeobox 1
Permalink
http://hdl.handle.net/11693/38109Published Version (Please cite this version)
https://doi.org/10.1007/s00109-016-1420-5Collections
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