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      Mammalian target of rapamycin (mTOR), aging, neuroscience, and their association with aging-related diseases

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      Author(s)
      Celebi-Birand, Ergül Dilan
      Karoğlu, Elif Tuğçe
      Doldur-Ballı, Füsun
      Adams, Michelle M.
      Editor
      Maiese, K.
      Date
      2016
      Publisher
      Elsevier Inc.
      Pages
      185 - 203
      Language
      English
      Type
      Book Chapter
      Item Usage Stats
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      Book Title
      Molecules to medicine with mTOR: translating critical pathways into novel therapeutic strategies
      Abstract
      Normal aging is accompanied by cognitive impairment with subtle cellular and molecular changes in the brain, whereas, pathological brain aging manifests as severe behavioral impairments with cellular pathology. Understanding the factors that contribute to both states is undoubtedly important for determining appropriate interventions that alter their progression. Mammalian target of rapamycin (mTOR) signaling has been implicated in affecting lifespan and age-related diseases such as cancer. The relationship of mTOR signaling with pathological brain aging has been more extensively studied, whereas the association with normal brain aging is not well understood. In this chapter we present information about normal and pathological brain aging, the relationship with mTOR signaling and use information from other age-related diseases to suggest that mTOR may have a role in promoting the cellular and molecular changes that underlie age-related cognitive changes. Future work should be directed towards understanding the precise role of mTOR signaling in brain aging. © 2016 Elsevier Inc. All rights reserved.
      Keywords
      Aging
      Cognitive decline
      Dementia
      Metabolism
      MTOR
      Neurodegenerative diseases
      Neuronal cells
      Synapses
      Permalink
      http://hdl.handle.net/11693/37781
      Published Version (Please cite this version)
      https://doi.org/10.1016/B978-0-12-802733-2.00007-4
      https://doi.org/10.1016/C2014-0-03321-7
      Collections
      • Aysel Sabuncu Brain Research Center (BAM) 249
      • Department of Molecular Biology and Genetics 542
      • Department of Psychology 242
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