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      Angiogenic peptide nanofibers repair cardiac tissue defect after myocardial infarction

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      Author
      Rufaihah, A. J.
      Yasa, I. C.
      Ramanujam, V. S.
      Arularasu, S. C.
      Kofidis, T.
      Güler, Mustafa O.
      Tekinay, A. B.
      Date
      2017
      Source Title
      Acta Biomaterialia
      Print ISSN
      1742-7061
      Electronic ISSN
      1878-7568
      Publisher
      Acta Materialia Inc
      Volume
      58
      Pages
      102 - 112
      Language
      English
      Type
      Article
      Item Usage Stats
      175
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      205
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      Abstract
      Myocardial infarction remains one of the top leading causes of death in the world and the damage sustained in the heart eventually develops into heart failure. Limited conventional treatment options due to the inability of the myocardium to regenerate after injury and shortage of organ donors require the development of alternative therapies to repair the damaged myocardium. Current efforts in repairing damage after myocardial infarction concentrates on using biologically derived molecules such as growth factors or stem cells, which carry risks of serious side effects including the formation of teratomas. Here, we demonstrate that synthetic glycosaminoglycan (GAG) mimetic peptide nanofiber scaffolds induce neovascularization in cardiovascular tissue after myocardial infarction, without the addition of any biologically derived factors or stem cells. When the GAG mimetic nanofiber gels were injected in the infarct site of rodent myocardial infarct model, increased VEGF-A expression and recruitment of vascular cells was observed. This was accompanied with significant degree of neovascularization and better cardiac performance when compared to the control saline group. The results demonstrate the potential of future clinical applications of these bioactive peptide nanofibers as a promising strategy for cardiovascular repair. Statement of Significance We present a synthetic bioactive peptide nanofiber system can enhance cardiac function and enhance cardiovascular regeneration after myocardial infarction (MI) without the addition of growth factors, stem cells or other biologically derived molecules. Current state of the art in cardiac repair after MI utilize at least one of the above mentioned biologically derived molecules, thus our approach is ground-breaking for cardiovascular therapy after MI. In this work, we showed that synthetic glycosaminoglycan (GAG) mimetic peptide nanofiber scaffolds induce neovascularization and cardiomyocyte differentiation for the regeneration of cardiovascular tissue after myocardial infarction in a rat infarct model. When the peptide nanofiber gels were injected in infarct site at rodent myocardial infarct model, recruitment of vascular cells was observed, neovascularization was significantly induced and cardiac performance was improved. These results demonstrate the potential of future clinical applications of these bioactive peptide nanofibers as a promising strategy for cardiovascular repair.
      Keywords
      Cardiomyocyte
      Myocardial infarction
      Neovascularization
      Peptide nanofibers
      VEGF
      Alpha smooth muscle actin
      Fibroblast growth factor 2
      Glycosaminoglycan
      Molecular scaffold
      Nanofiber
      Scatter factor
      Sodium chloride
      Troponin T
      Vasculotropin A
      Angiogenic factor
      Nanofiber
      Peptide
      Vascular endothelial growth factor A, rat
      Vasculotropin A
      Animal cell
      Animal experiment
      Animal model
      Article
      Cell adhesion
      Cell differentiation
      Cell fate
      Controlled study
      Heart function
      Heart infarction
      Heart left ventricle pressure
      Heart muscle contractility
      Heart output
      Heart performance
      Heart tissue
      Male
      Neovascularization (pathology)
      Nonhuman
      Priority journal
      Protein expression
      Rat
      Stem cell
      Animal
      Biosynthesis
      Cardiac muscle
      Chemistry
      Disease model
      Heart infarction
      Metabolism
      Pathology
      Wistar rat
      Angiogenesis inducing agents
      Animals
      Disease models, animal
      Male
      Myocardial infarction
      Myocardium
      Nanofibers
      Peptides
      Rats
      Rats, wistar
      Vascular endothelial growth factor A
      Permalink
      http://hdl.handle.net/11693/37443
      Published Version (Please cite this version)
      http://dx.doi.org/10.1016/j.actbio.2017.06.009
      Collections
      • Institute of Materials Science and Nanotechnology (UNAM) 1775
      • Nanotechnology Research Center (NANOTAM) 1006
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