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      Heparin mimetic peptide nanofiber gel promotes regeneration of full thickness burn injury

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      Embargo Lift Date: 2019-07-01
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      Author(s)
      Yergoz, F.
      Hastar, N.
      Cimenci, C. E.
      Ozkan, A. D.
      Güler, Mustafa O.
      Tekinay, A. B.
      Tekinay, T.
      Güler, Mustafa O.
      Date
      2017
      Source Title
      Biomaterials
      Print ISSN
      0142-9612
      Publisher
      Elsevier Ltd
      Volume
      134
      Pages
      117 - 127
      Language
      English
      Type
      Article
      Item Usage Stats
      274
      views
      681
      downloads
      Abstract
      Burn injuries are one of the most common types of trauma worldwide, and their unique physiology requires the development of specialized therapeutic materials for their treatment. Here, we report the use of synthetic, functional and biodegradable peptide nanofiber gels for the improved healing of burn wounds to alleviate the progressive loss of tissue function at the post-burn wound site. These bioactive nanofiber gels form scaffolds that recapitulate the structure and function of the native extracellular matrix through signaling peptide epitopes, which can trigger angiogenesis through their affinity to basic growth factors. In this study, the angiogenesis-promoting properties of the bioactive scaffolds were utilized for the treatment of a thermal burn model. Following the excision of necrotic tissue, bioactive gels and control solutions were applied topically onto the wound area. The wound healing process was evaluated at 7, 14 and 21 days following injury through histological observations, immunostaining and marker RNA/protein analysis. Bioactive peptide nanofiber-treated burn wounds formed well-organized and collagen-rich granulation tissue layers, produced a greater density of newly formed blood vessels, and exhibited increased re-epithelialization and skin appendage development with minimal crust formation, while non-bioactive peptide nanofibers and the commercial wound dressing 3M™ Tegaderm™ did not exhibit significant efficiency over sucrose controls. Overall, the heparin-mimetic peptide nanofiber gels increased the rate of repair of burn injuries and can be used as an effective means of facilitating wound healing.
      Keywords
      Burn injury
      Heparin
      Hydrogel
      Peptide nanofiber
      Self-assembly
      Blood vessels
      Gels
      High temperature effects
      Hydrogels
      Nanofibers
      Peptides
      Polysaccharides
      Self assembly
      Tissue
      Tissue regeneration
      Bioactive nanofibers
      Burn injury
      Heparin
      Histological observations
      Native extracellular matrix
      Re-epithelialization
      Therapeutic materials
      Wound healing process
      Biomimetics
      Collagen
      Heparin
      Nanofiber
      RNA
      Heparin
      Nanofiber
      Peptide
      Angiogenesis
      Animal experiment
      Animal model
      Animal tissue
      Article
      Burn
      Controlled study
      Debridement
      Density
      Epithelization
      Full thickness skin graft
      Gel
      Immunohistochemistry
      In vivo study
      Male
      Mouse
      Nonhuman
      Priority journal
      RNA analysis
      Skin appendage
      Tissue regeneration
      Wound dressing
      Wound healing
      Animal
      Bagg albino mouse
      Burn
      Chemistry
      Circular dichroism
      Gel
      Physiology
      Scanning electron microscopy
      Tissue scaffold
      Animals
      Burns
      Circular dichroism
      Gels
      Heparin
      Immunohistochemistry
      Male
      Mice
      Mice, inbred BALB C
      Microscopy, electron, scanning
      Nanofibers
      Peptides
      Tissue scaffolds
      Wound healing
      Permalink
      http://hdl.handle.net/11693/37432
      Published Version (Please cite this version)
      http://dx.doi.org/10.1016/j.biomaterials.2017.04.040
      Collections
      • Institute of Materials Science and Nanotechnology (UNAM) 2255
      • Nanotechnology Research Center (NANOTAM) 1179
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