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      Controlled enzymatic stability and release characteristics of supramolecular chiral peptide amphiphile nanofiber gels

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      Embargo Lift Date: 2019-05-01
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      Author(s)
      Zengin, A.
      Cinar, G.
      Güler, Mustafa O.
      Date
      2017
      Source Title
      Current Applied Physics
      Print ISSN
      1567-1739
      Electronic ISSN
      1878-1675
      Publisher
      Elsevier B.V.
      Volume
      17
      Issue
      5
      Pages
      785 - 792
      Language
      English
      Type
      Article
      Item Usage Stats
      208
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      244
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      Abstract
      Supramolecular bioarchitectures formed by assembly of achiral or chiral building blocks play important roles in various biochemical processes. Stereochemistry of amino acids is important for structural organization of peptide and protein assemblies and structure-microenvironment interactions. In this study, oppositely charged peptide amphiphile (PA) molecules with L-, D- and mixture of L- and D-amino acid conformations are coassembled into supramolecular nanofibers and formed self-supporting gels at pH 7.4 in water. The enzymatic stability of the PA nanofiber gels was studied in the presence of proteinase K enzyme, which digest a broad spectrum of proteins and peptides. The structural changes on the chiral PA nanofibers were also analyzed at different time periods in the presence of enzymatic activity. Controlled release of a model cargo molecule through the chiral PA nanofiber gels was monitored. The diffusivity parameters were measured for all gel systems. Release characteristics and the enzymatic stability of the peptide nanofiber gels were modulated depending on organization of the chiral PA molecules within the supramolecular assemblies.
      Keywords
      Controlled release
      Enzymatic stability
      Nanofibers
      Peptide amphiphile
      Self-assembly
      Supramolecular chirality
      Amino acids
      Amphiphiles
      Enzyme activity
      Gels
      Molecules
      Nanofibers
      Peptides
      Proteins
      Self assembly
      Stability
      Supramolecular chemistry
      Chiral building blocks
      Controlled release
      Enzymatic stability
      Peptide amphiphiles
      Release characteristics
      Structural organization
      Supramolecular assemblies
      Supramolecular chirality
      Stereochemistry
      Permalink
      http://hdl.handle.net/11693/37431
      Published Version (Please cite this version)
      http://dx.doi.org/10.1016/j.cap.2017.02.026
      Collections
      • Institute of Materials Science and Nanotechnology (UNAM) 2256
      • Nanotechnology Research Center (NANOTAM) 1179
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