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      Polymer-free electrospun nanofibers from sulfobutyl ether7-beta-cyclodextrin (SBE7-β-CD) inclusion complex with sulfisoxazole: fast-dissolving and enhanced water-solubility of sulfisoxazole

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      Author(s)
      Yildiz, Z. I.
      Celebioglu A.
      Uyar, Tamer
      Date
      2017-10
      Source Title
      International Journal of Pharmaceutics
      Print ISSN
      0378-5173
      Publisher
      Elsevier
      Volume
      531
      Issue
      2
      Pages
      550 - 558
      Language
      English
      Type
      Article
      Item Usage Stats
      236
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      407
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      Abstract
      In this study, our aim was to develop solid drug-cyclodextrin inclusion complex system having nanofibrous morphology in order to have fast-dissolving property and enhanced water-solubility of poorly water-soluble drug. Here, we prepared a highly concentrated aqueous solution of inclusion complex between sulfisoxazole and sulfobutyl ether7-beta-cyclodextrin (SBE7-β-CD, Captisol®), and then, without using any polymeric matrix, the electrospinning of sulfisoxazole/SBE7-β-CD-IC nanofibers was performed in order to obtain free-standing and handy nanofibrous web. As a control sample, nanofibers from pure SBE7-β-CD was also electrospun and free-standing nanofibrous web was obtained. The SEM imaging revealed that the bead-free and uniform nanofiber morphology with the average fiber diameter (AFD) of 650 ± 290 nm for sulfisoxazole/SBE7-β-CD-IC NF and 890 ± 415 nm for pure SBE7-β-CD NF was obtained. The inclusion complex formation between sulfisoxazole and SBE7-β-CD in sulfisoxazole/SBE7-β-CD-IC NF sample was confirmed by 1H NMR, TGA, DSC, XRD and FTIR analyses. Due to the combined advantage of cyclodextrin inclusion complexation and high surface area of electrospun nanofibers, fast-dissolving property with enhanced water-solubility was successfully achieved for sulfisoxazole/SBE7-β-CD-IC NF. Our findings suggest that electrospun nanofibers/nanowebs from CD-IC of poorly water-soluble drugs may offer applicable approaches for high water-solubility and fast-dissolving tablet formulations for drug delivery systems.
      Keywords
      Electrospinning
      Electrospun nanofibers
      Inclusion complex
      Sulfisoxazole
      Sulfobutyl ether7-beta-cyclodextrin (Captisol®)
      Water-Solubility
      Beta cyclodextrin sulfobutyl ether
      Nanofiber
      Polymer
      Sulfafurazole
      Water
      Beta cyclodextrin derivative
      Drug carrier
      Permalink
      http://hdl.handle.net/11693/37380
      Published Version (Please cite this version)
      https://doi.org/10.1016/j.ijpharm.2017.04.047
      Collections
      • Institute of Materials Science and Nanotechnology (UNAM) 2260
      • Nanotechnology Research Center (NANOTAM) 1179
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