Built-up edge (BUE) is generally known to cause surface finish problems in the micro milling process. The loose particles from the BUE may be deposited on the machined surface, causing surface roughness to increase. On the other hand, a stable BUE formation may protect the tool from rapid tool wear, which hinders the productivity of the micro milling process. Despite its common presence in practice, the influence of BUE on the process outputs of micro milling has not been studied in detail. This paper investigates the relationship between BUE formation and process outputs in micro milling of titanium alloy Ti6Al4V using an experimental approach. Micro end mills used in this study are fabricated to have a single straight edge using wire electrical discharge machining. An initial experimental effort was conducted to study the relationship between micro cutting tool geometry, surface roughness, and micro milling process forces and hence conditions to form stable BUE on the tool tip have been identified. The influence of micro milling process conditions on BUE size, and their combined effect on forces, surface roughness, and burr formation is investigated. Long-term micro milling experiment was performed to observe the protective effect of BUE on tool life. The results show that tailored micro cutting tools having stable BUE can be designed to machine titanium alloys with long tool life with acceptable surface quality. © 2017 Elsevier Inc.