A smartphone based surface plasmon resonance imaging (SPRi) platform for on-site biodetection
Embargo Lift Date: 2019-02-01
Sensors and Actuators, B: Chemical
571 - 577
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We demonstrate a surface plasmon resonance imaging platform integrated with a smartphone to be used in the field with high-throughput biodetection. Inexpensive and disposable SPR substrates are produced by metal coating of commercial Blu-ray discs. A compact imaging apparatus is fabricated using a 3D printer which allows taking SPR measurements from more than 20.000 individual pixels. Real-time bulk refractive index change measurements yield noise equivalent refractive index changes as low as 4.12 × 10−5 RIU which is comparable with the detection performance of commercial instruments. As a demonstration of a biological assay, we have shown capture of mouse IgG antibodies by immobilized layer of rabbit anti-mouse (RAM) IgG antibody with nanomolar level limit of detection. Our approach in miniaturization of SPR biosensing in a cost-effective manner could enable realization of portable SPR measurement systems and kits for point-of-care applications.
Surface plasmon resonance imaging
Semiconductor quantum wells
Equivalent refractive index
Refractive index changes
Surface plasmon resonance
Published Version (Please cite this version)http://dx.doi.org/10.1016/j.snb.2016.08.061
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