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      One-Step Fabrication of Biocompatible Multifaceted Nanocomposite Gels and Nanolayers

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      Author(s)
      Topuz, F.
      Bartneck, M.
      Pan, Y.
      Tacke, F.
      Date
      2017
      Source Title
      Biomacromolecules
      Print ISSN
      1525-7797
      Electronic ISSN
      1526-4602
      Publisher
      American Chemical Society
      Volume
      18
      Issue
      2
      Pages
      386 - 397
      Language
      English
      Type
      Article
      Item Usage Stats
      220
      views
      361
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      Abstract
      Nanocomposite gels are a fascinating class of polymeric materials with an integrative assembly of organic molecules and organic/inorganic nanoparticles, offering a unique hybrid network with synergistic properties. The mechanical properties of such networks are similar to those of natural tissues, which make them ideal biomaterial candidates for tissue engineering applications. Existing nanocomposite gel systems, however, lack many desirable gel properties, and their suitability for surface coatings is often limited. To address this issue, this article aims at generating multifunctional nanocomposite gels that are injectable with an appropriate time window, functional with bicyclononynes (BCN), biocompatible and slowly degradable, and possess high mechanical strength. Further, the in situ network-forming property of the proposed system allows the fabrication of ultrathin nanocomposite coatings in the submicrometer range with tunable wettability and roughness. Multifunctional nanocomposite gels were fabricated under cytocompatible conditions (pH 7.4 and T = 37 °C) using laponite clays, isocyanate (NCO)-terminated sP(EO-stat-PO) macromers, and clickable BCN. Several characterization techniques were employed to elucidate the structure-property relationships of the gels. Even though the NCO-sP(EO-stat-PO) macromers could form a hydrogel network in situ on contact with water, the incorporation of laponite led to significant improvement of the mechanical properties. BCN motifs with carbamate links were used for a metal-free click ligation with azide-functional molecules, and the subsequent gradual release of the tethered molecules through the hydrolysis of carbamate bonds was shown. The biocompatibility of the hydrogels was examined through murine macrophages, showing that the material composition strongly affects cell behavior.
      Keywords
      Biocompatibility
      Biomechanics
      Characterization
      Coatings
      Fabrication
      Gels
      Hybrid materials
      Mechanical properties
      Molecules
      Tissue
      Tissue engineering
      Characterization techniques
      High mechanical strength
      Material compositions
      Multifunctional nanocomposites
      Nano-composite coating
      Structure property relationships
      Synergistic properties
      Tissue engineering applications
      Animals
      Biocompatible materials
      Cell adhesion
      Cells cultured
      Hydrogels
      Macrophages
      Mice
      Nanocomposites
      Polymers
      Permalink
      http://hdl.handle.net/11693/37307
      Published Version (Please cite this version)
      http://dx.doi.org/10.1021/acs.biomac.6b01483
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      • Institute of Materials Science and Nanotechnology (UNAM) 2258
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