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dc.contributor.authorCelebioglu A.en_US
dc.contributor.authorUyar T.en_US
dc.date.accessioned2018-04-12T11:09:15Z
dc.date.available2018-04-12T11:09:15Z
dc.date.issued2017en_US
dc.identifier.issn0021-8561
dc.identifier.urihttp://hdl.handle.net/11693/37302
dc.description.abstractHere, we demonstrated the electrospinning of polymer-free nanofibrous webs from inclusion complex (IC) between hydroxypropyl-β-cyclodextrin (HPβCD) and Vitamin E (Vitamin E/HPβCD-IC NF). The inclusion complexation between HPβCD and Vitamin E was prepared by using two different molar ratios (Vitamin E/HPβCD; 1:2 and 1:1), which correspond to theoretical value of ∼13% (w/w) and 26% (w/w) loading of Vitamin E in the nanofiber (NF) matrix. After electrospinning and storage, a very high loading of Vitamin E (up to ∼11% w/w, with respect to fiber matrix) was preserved in Vitamin E/HPβCD-IC NF. Because of the cyclodextrin inclusion complexation, only a minimal weight loss (only ∼2% w/w) was observed. While pure Vitamin E is insoluble in water, Vitamin E/HPβCD-IC NF web has displayed fast-dissolving behavior. Because of the greatly enhanced water-solubility of Vitamin E, Vitamin E/HPβCD-IC NF web has shown effective antioxidant activity. Additionally, Vitamin E/HPβCD-IC NF web has provided enhanced photostability for the sensitive Vitamin E by the inclusion complexation in which Vitamin E/HPβCD-IC NF still kept its antioxidant activity even after exposure to UV-light. Moreover, a 3 year-old Vitamin E/HPβCD-IC NF sample has shown very similar antioxidant efficiency when compared with freshly prepared Vitamin E/HPβCD-IC NF indicating that long-term stability was achieved for Vitamin E in the CD-IC fiber matrix. In brief, our results suggested that polymer-free electrospun Vitamin E/HPβCD-IC nanofibrous webs could have potential applications in food, pharmaceuticals, and healthcare thanks to its efficient antioxidant activity along with enhanced water-solubility, prolonged shelf life, and high photostability of Vitamin E.en_US
dc.language.isoEnglishen_US
dc.source.titleJournal of Agricultural and Food Chemistryen_US
dc.relation.isversionofhttps://doi.org/10.1021/acs.jafc.7b01562en_US
dc.subjectAntioxidant activityen_US
dc.subjectCyclodextrinsen_US
dc.subjectElectrospinningen_US
dc.subjectInclusion complexen_US
dc.subjectNanofibersen_US
dc.subjectPhotostabilityen_US
dc.subjectVitamin E (alpha-tocopherol)en_US
dc.subjectWater-solubilityen_US
dc.subjectAntioxidantsen_US
dc.subjectCyclodextrinsen_US
dc.subjectElectrospinningen_US
dc.subjectFood preservationen_US
dc.subjectNanofibersen_US
dc.subjectSolubilityen_US
dc.subjectSpinning (fibers)en_US
dc.subjectAnti-oxidant activitiesen_US
dc.subjectInclusion complexen_US
dc.subjectPhoto-stabilityen_US
dc.subjectVitamin-Een_US
dc.subjectWater solubilitiesen_US
dc.subjectIntegrated circuitsen_US
dc.subjectAlpha tocopherolen_US
dc.subjectAntioxidanten_US
dc.subjectCyclodextrinen_US
dc.subjectDrug carrieren_US
dc.subjectNanofiberen_US
dc.subjectChemistryen_US
dc.subjectDrug formulationen_US
dc.subjectDrug stabilityen_US
dc.subjectLighten_US
dc.subjectParticle sizeen_US
dc.subjectRadiation responseen_US
dc.subjectSolubilityen_US
dc.subjectAntioxidantsen_US
dc.subjectCyclodextrinsen_US
dc.subjectDrug Carriersen_US
dc.subjectDrug Compoundingen_US
dc.subjectDrug Stabilityen_US
dc.subjectLighten_US
dc.subjectNanofibersen_US
dc.subjectParticle Sizeen_US
dc.subjectSolubilityen_US
dc.subjectVitamin Een_US
dc.titleAntioxidant vitamin E/cyclodextrin inclusion complex electrospun nanofibers: enhanced water solubility, prolonged shelf life, and photostability of vitamin Een_US
dc.typeArticleen_US
dc.departmentUNAM - Institute of Materials Science and Nanotechnology
dc.departmentNanotechnology Research Centeren_US
dc.citation.spage5404en_US
dc.citation.epage5412en_US
dc.citation.volumeNumber65en_US
dc.citation.issueNumber26en_US
dc.identifier.doi10.1021/acs.jafc.7b01562en_US
dc.publisherAmerican Chemical Societyen_US


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