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dc.contributor.authorBeter, M.en_US
dc.contributor.authorKara, H. K.en_US
dc.contributor.authorTopal, A. E.en_US
dc.contributor.authorDana, A.en_US
dc.contributor.authorTekinay, A. B.en_US
dc.contributor.authorGuler, M. O.en_US
dc.date.accessioned2018-04-12T11:08:48Z
dc.date.available2018-04-12T11:08:48Z
dc.date.issued2017en_US
dc.identifier.issn1543-8384
dc.identifier.urihttp://hdl.handle.net/11693/37289
dc.description.abstractNoncovalent and electrostatic interactions facilitate the formation of complex networks through molecular self-assembly in biomolecules such as proteins and glycosaminoglycans. Self-assembling peptide amphiphiles (PA) are a group of molecules that can form nanofibrous structures and may contain bioactive epitopes to interact specifically with target molecules. Here, we report the presentation of cationic peptide sequences on supramolecular nanofibers formed by self-assembling peptide amphiphiles for cooperative enhanced antibacterial activity. Antibacterial properties of self-assembled peptide nanofibers were significantly higher than soluble peptide molecules with identical amino acid sequences, suggesting that the tandem presentation of bioactive epitopes is important for designing new materials for bactericidal activity. In addition, bacteria were observed to accumulate more rapidly on peptide nanofibers compared to soluble peptides, which may further enhance antibacterial activity by increasing the number of peptide molecules interacting with the bacterial membrane. The cationic peptide amphiphile nanofibers were observed to attach to bacterial membranes and disrupt their integrity. These results demonstrate that short cationic peptides show a significant improvement in antibacterial activity when presented in the nanofiber form.en_US
dc.language.isoEnglishen_US
dc.source.titleMolecular Pharmaceuticsen_US
dc.relation.isversionofhttps://doi.org/10.1021/acs.molpharmaceut.7b00434en_US
dc.subjectAntibacterial peptideen_US
dc.subjectCationic peptideen_US
dc.subjectMultivalent presentationen_US
dc.subjectPeptide nanofiberen_US
dc.subjectAmphophileen_US
dc.subjectAntimicrobial cationic peptideen_US
dc.subjectEpitopeen_US
dc.subjectGlycosaminoglycanen_US
dc.subjectNanofiberen_US
dc.subjectAmino acid sequenceen_US
dc.subjectAntibacterial activityen_US
dc.subjectAntimicrobial activityen_US
dc.subjectArticleen_US
dc.subjectBacillus subtilisen_US
dc.subjectBacterial membraneen_US
dc.subjectBactericidal activityen_US
dc.subjectBeta sheeten_US
dc.subjectComplex formationen_US
dc.subjectControlled studyen_US
dc.subjectEscherichia colien_US
dc.subjectHumanen_US
dc.subjectHuman cellen_US
dc.subjectMinimum inhibitory concentrationen_US
dc.subjectMolecular interactionen_US
dc.subjectNonhumanen_US
dc.subjectPriority journalen_US
dc.subjectSupramolecular chemistryen_US
dc.titleMultivalent presentation of cationic peptides on supramolecular nanofibers for antimicrobial activityen_US
dc.typeArticleen_US
dc.departmentInstitute of Materials Science and Nanotechnology (UNAM)en_US
dc.citation.spage3660en_US
dc.citation.epage3668en_US
dc.citation.volumeNumber14en_US
dc.citation.issueNumber11en_US
dc.identifier.doi10.1021/acs.molpharmaceut.7b00434en_US
dc.publisherAmerican Chemical Societyen_US


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