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      Antigenic GM3 lactone mimetic molecule integrated mannosylated glycopeptide nanofibers for the activation and maturation of dendritic cells

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      Author
      Gunay, Gokhan
      Ekiz, Melis Sardan
      Ferhati, X.
      Richichi, B.
      Nativi, C.
      Tekinay, Ayse B.
      Güler, Mustafa O.
      Date
      2017
      Source Title
      ACS Applied Materials and Interfaces
      Print ISSN
      1944-8244
      Publisher
      American Chemical Society
      Volume
      9
      Issue
      19
      Pages
      16035 - 16042
      Language
      English
      Type
      Article
      Item Usage Stats
      170
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      168
      downloads
      Abstract
      The ability of dendritic cells to coordinate innate and adaptive immune responses makes them essential targets for vaccination strategies. Presentation of specific antigens by dendritic cells is required for the activation of the immune system against many pathogens and tumors, and nanoscale materials can be functionalized for active targeting of dendritic cells. In this work, we integrated an immunogenic, carbohydrate melanoma-associated antigen-mimetic GM3-lactone molecule into mannosylated peptide amphiphile nanofibers to target dendritic cells through DC-SIGN receptor. Based on morphological and functional analyses, when dendritic cells were treated with peptide nanofiber carriers, they showed significant increase in antigen internalization and a corresponding increase in the surface expression of the activation and maturation markers CD86, CD83 and HLA-DR, in addition to exhibiting a general morphology consistent with dendritic cell maturation. These results indicate that mannosylated peptide amphiphile nanofiber carriers are promising candidates to target dendritic cells for antigen delivery. © 2017 American Chemical Society.
      Keywords
      Cancer antigens
      Carbohydrate melanoma associated antigen
      Dendritic cells
      Amphiphiles
      Antigens
      Biomimetics
      Carbohydrates
      Chemical activation
      Cytology
      Dermatology
      Diseases
      Esters
      Immune system
      Molecules
      Nanofibers
      Oncology
      Peptides
      Polypeptides
      Adaptive immune response
      Antigen delivery
      Cancer immunotherapy
      Dendritic cells
      Nano-scale materials
      Peptide amphiphiles
      Surface expression
      Vaccination strategy
      Cells
      Permalink
      http://hdl.handle.net/11693/37285
      Published Version (Please cite this version)
      http://dx.doi.org/10.1021/acsami.7b04094
      Collections
      • Aysel Sabuncu Brain Research Center (BAM) 197
      • Institute of Materials Science and Nanotechnology (UNAM) 1858
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