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      Angiogenic heparin-mimetic peptide nanofiber gel improves regenerative healing of acute wounds

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      Author
      Uzunalli, G.
      Mammadov R.
      Yesildal, F.
      Alhan, D.
      Ozturk, S.
      Ozgurtas, T.
      Güler, Mustafa O.
      Tekinay, A. B.
      Date
      2017
      Source Title
      ACS Biomaterials Science and Engineering
      Print ISSN
      2373-9878
      Publisher
      American Chemical Society
      Volume
      3
      Issue
      7
      Pages
      1296 - 1303
      Language
      English
      Type
      Article
      Item Usage Stats
      163
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      140
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      Abstract
      Wound repair in adult mammals typically ends with the formation of a scar, which prevents full restoration of the function of the healthy tissue, although most of the wounded skin heals. Rapid and functional recovery of major wound injuries requires therapeutic approaches that can enhance the healing process via overcoming mechanical and biochemical problems. In this study, we showed that self-assembled heparin-mimetic peptide nanofiber gel was an effective bioactive wound dressing for the rapid and functional repair of full-thickness excisional wounds in the rat model. The bioactive gel-treated wounds exhibited increased angiogenesis (p < 0.05), re-epithelization (p < 0.05), skin appendage formation, and granulation tissue organization (p < 0.05) compared to sucrose-treated samples. Increased blood vessel numbers in the gel-treated wounds on day 7 suggest that angiogenesis played a key role in improvement of tissue healing in bioactive gel-treated wounds. Overall, the angiogenic heparin-mimetic peptide nanofiber gel is a promising platform for enhancing the scar-free recovery of acute wounds.
      Keywords
      Angiogenesis
      Heparin-mimetic peptide nanofiber
      Self-assembly
      Wound healing
      Amphophile
      Heparin
      Heparin mimetic peptide nanofiber
      Nanofiber
      Peptidomimetic agent
      Unclassified drug
      Wound healing promoting agent
      Angiogenesis
      Animal experiment
      Animal model
      Animal tissue
      Article
      Blood vessel
      Controlled study
      Epithelization
      Female
      Gel
      Granulation tissue
      Histology
      In vivo study
      Male
      Nonhuman
      Priority journal
      Rat
      Scar formation
      Skin appendage
      Skin injury
      Vascularization
      Wound closure
      Wound healing
      Permalink
      http://hdl.handle.net/11693/37283
      Published Version (Please cite this version)
      https://doi.org/10.1021/acsbiomaterials.6b00165
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      • Institute of Materials Science and Nanotechnology (UNAM) 1775
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