Angiogenic heparin-mimetic peptide nanofiber gel improves regenerative healing of acute wounds
Author
Uzunalli, G.
Mammadov R.
Yesildal, F.
Alhan, D.
Ozturk, S.
Ozgurtas, T.
Guler, M. O.
Tekinay, A. B.
Date
2017Source Title
ACS Biomaterials Science and Engineering
Print ISSN
2373-9878
Publisher
American Chemical Society
Volume
3
Issue
7
Pages
1296 - 1303
Language
English
Type
ArticleItem Usage Stats
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Metadata
Show full item recordAbstract
Wound repair in adult mammals typically ends with the formation of a scar, which prevents full restoration of the function of the healthy tissue, although most of the wounded skin heals. Rapid and functional recovery of major wound injuries requires therapeutic approaches that can enhance the healing process via overcoming mechanical and biochemical problems. In this study, we showed that self-assembled heparin-mimetic peptide nanofiber gel was an effective bioactive wound dressing for the rapid and functional repair of full-thickness excisional wounds in the rat model. The bioactive gel-treated wounds exhibited increased angiogenesis (p < 0.05), re-epithelization (p < 0.05), skin appendage formation, and granulation tissue organization (p < 0.05) compared to sucrose-treated samples. Increased blood vessel numbers in the gel-treated wounds on day 7 suggest that angiogenesis played a key role in improvement of tissue healing in bioactive gel-treated wounds. Overall, the angiogenic heparin-mimetic peptide nanofiber gel is a promising platform for enhancing the scar-free recovery of acute wounds.
Keywords
AngiogenesisHeparin-mimetic peptide nanofiber
Self-assembly
Wound healing
Amphophile
Heparin
Heparin mimetic peptide nanofiber
Nanofiber
Peptidomimetic agent
Unclassified drug
Wound healing promoting agent
Angiogenesis
Animal experiment
Animal model
Animal tissue
Article
Blood vessel
Controlled study
Epithelization
Female
Gel
Granulation tissue
Histology
In vivo study
Male
Nonhuman
Priority journal
Rat
Scar formation
Skin appendage
Skin injury
Vascularization
Wound closure
Wound healing
Permalink
http://hdl.handle.net/11693/37283Published Version (Please cite this version)
https://doi.org/10.1021/acsbiomaterials.6b00165Collections
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