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      Local delivery of doxorubicin through supramolecular peptide amphiphile nanofiber gels

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      Author(s)
      Cinar, G.
      Ozdemir, A.
      Hamsici, S.
      Gunay, G.
      Dana, A.
      Tekinay, A. B.
      Güler, Mustafa O.
      Date
      2017
      Source Title
      Biomaterials Science
      Print ISSN
      2047-4830
      Publisher
      Royal Society of Chemistry
      Volume
      5
      Issue
      1
      Pages
      67 - 76
      Language
      English
      Type
      Article
      Item Usage Stats
      204
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      502
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      Abstract
      Peptide amphiphiles (PAs) self-assemble into supramolecular nanofiber gels that provide a suitable environment for encapsulation of both hydrophobic and hydrophilic molecules. The PA gels have significant advantages for controlled delivery applications due to their high capacity to retain water, biocompatibility, and biodegradability. In this study, we demonstrate injectable supramolecular PA nanofiber gels for drug delivery applications. Doxorubicin (Dox), as a widely used chemotherapeutic drug for breast cancer treatment, was encapsulated within the PA gels prepared at different concentrations. Physical and chemical properties of the gels were characterized, and slow release of the Dox molecules through the supramolecular PA nanofiber gels was studied. In addition, the diffusion constants of the drug molecules within the PA nanofiber gels were estimated using fluorescence recovery after the photobleaching (FRAP) method. The PA nanofiber gels did not show any cytotoxicity and the encapsulation strategy enhanced the activity of drug molecules on cellular viability through prolonged release compared to direct administration under in vitro conditions. Moreover, the local in vivo injection of the Dox encapsulated PA nanofiber gels (Dox/PA) to the tumor site demonstrated the lowest tumor growth rate compared to the direct Dox injection and increased the apoptotic cells within the tumor tissue for local drug release through the PA nanofiber gels under in vivo conditions.
      Keywords
      Amphiphiles
      Biocompatibility
      Biodegradability
      Molecules
      Nanofibers
      Peptides
      Photobleaching
      Polypeptides
      Supramolecular chemistry
      Tumors
      Breast cancer treatment
      Chemotherapeutic drugs
      Controlled delivery
      Drug delivery applications
      Fluorescence recovery
      Hydrophobic and hydrophilic
      Peptide amphiphiles
      Physical and chemical properties
      Gels
      Amphophile
      Doxorubicin
      Nanofiber
      Peptide
      Doxorubicin
      Nanofiber
      Peptide
      Surfactant
      Animal experiment
      Animal model
      Animal tissue
      Article
      Bleaching
      Breast cancer cell line
      Breast carcinoma
      Cell viability
      Concentration (parameters)
      Controlled study
      Cytotoxicity
      Drug delivery system
      Drug release
      Female
      Mouse
      Nanoencapsulation
      Nonhuman
      Physical chemistry
      Priority journal
      Breast tumor
      Chemical phenomena
      Permalink
      http://hdl.handle.net/11693/37254
      Published Version (Please cite this version)
      https://doi.org/10.1039/c6bm00656f
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      • Institute of Materials Science and Nanotechnology (UNAM) 2256
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