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dc.contributor.authorYasa, Oncayen_US
dc.contributor.authorUysal, Ozgeen_US
dc.contributor.authorEkiz, Melis Sardanen_US
dc.contributor.authorGuler, Mustafa O.en_US
dc.contributor.authorTekinay, Ayse B.en_US
dc.date.accessioned2018-04-12T11:06:43Z
dc.date.available2018-04-12T11:06:43Z
dc.date.issued2017en_US
dc.identifier.issn2050-7518
dc.identifier.urihttp://hdl.handle.net/11693/37233
dc.description.abstractOrganizational complexity and functional diversity of the extracellular matrix regulate cellular behaviors. The extracellular matrix is composed of various proteins in the form of proteoglycans, glycoproteins, and nanofibers whose types and combinations change depending on the tissue type. Proteoglycans, which are proteins that are covalently attached to glycosaminoglycans, contribute to the complexity of the microenvironment of the cells. The sulfation degree of the glycosaminoglycans is an important and distinct feature at specific developmental stages and tissue types. Peptide amphiphile nanofibers can mimic natural glycosaminoglycans and/or proteoglycans, and they form a synthetic nanofibrous microenvironment where cells can proliferate and differentiate towards different lineages. In this study, peptide nanofibers were used to provide varying degrees of sulfonation mimicking the natural glycosaminoglycans by forming a microenvironment for the survival and differentiation of stem cells. The effects of glucose, carboxylate, and sulfonate groups on the peptide nanofibers were investigated by considering the changes in the differentiation profiles of rat mesenchymal stem cells in the absence of any specific differentiation inducers in the culture medium. The results showed that a higher sulfonate-to-glucose ratio is associated with adipogenic differentiation and a higher carboxylate-to-glucose ratio is associated with osteochondrogenic differentiation of the rat mesenchymal stem cells. Overall, these results demonstrate that supramolecular peptide nanosystems can be used to understand the fine-tunings of the extracellular matrix such as sulfation profile on specific cell types. © 2017 The Royal Society of Chemistry.en_US
dc.language.isoEnglishen_US
dc.source.titleJournal of Materials Chemistry Ben_US
dc.relation.isversionofhttp://dx.doi.org/10.1039/c7tb00708fen_US
dc.subjectCarboxylationen_US
dc.subjectCell cultureen_US
dc.subjectCytologyen_US
dc.subjectEnzyme activityen_US
dc.subjectGlucoseen_US
dc.subjectGlycoproteinsen_US
dc.subjectNanofibersen_US
dc.subjectPeptidesen_US
dc.subjectProteinsen_US
dc.subjectRatsen_US
dc.subjectStem cellsen_US
dc.subjectSupramolecular chemistryen_US
dc.subjectTissueen_US
dc.subjectAdipogenic differentiationsen_US
dc.subjectCellular behaviorsen_US
dc.subjectDevelopmental stageen_US
dc.subjectExtracellular matricesen_US
dc.subjectFunctional diversityen_US
dc.subjectMesenchymal stem cellen_US
dc.subjectOrganizational complexityen_US
dc.subjectPeptide amphiphilesen_US
dc.subjectCellsen_US
dc.titlePresentation of functional groups on self-assembled supramolecular peptide nanofibers mimicking glycosaminoglycans for directed mesenchymal stem cell differentiationen_US
dc.typeArticleen_US
dc.departmentInterdisciplinary Program in Neuroscience (NEUROSCIENCE)en_US
dc.departmentInstitute of Materials Science and Nanotechnology (UNAM)en_US
dc.departmentAysel Sabuncu Brain Research Center (BAM)en_US
dc.citation.spage4890en_US
dc.citation.epage4900en_US
dc.citation.volumeNumber5en_US
dc.citation.issueNumber25en_US
dc.identifier.doi10.1039/c7tb00708fen_US
dc.publisherRoyal Society of Chemistryen_US
dc.contributor.bilkentauthorYasa, Oncay
dc.contributor.bilkentauthorUysal, Ozge
dc.contributor.bilkentauthorEkiz, Melis Sardan
dc.contributor.bilkentauthorGuler, Mustafa O.
dc.contributor.bilkentauthorTekinay, Ayse B.


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