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      Influence of cigarette smoking on white matter in patients with clinically isolated syndrome as detected by diffusion tensor imaging

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      Author(s)
      Durhan, G.
      Diker, S.
      Has, A. C.
      Karakaya, J.
      Kurne, A. T.
      Oguz, K. K.
      Date
      2016
      Source Title
      Diagnostic and Interventional Radiology
      Print ISSN
      1305-3825
      Publisher
      Turkish Society of Radiology
      Volume
      22
      Issue
      3
      Pages
      291 - 296
      Language
      English
      Type
      Article
      Item Usage Stats
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      Abstract
      PURPOSE Cigarette smoking has been associated with increased occurrence of multiple sclerosis (MS), as well as clinical disability and disease progression in MS. We aimed to assess the effects of smoking on the white matter (WM) in patients with clinically isolated syndrome (CIS) using diffusion tensor imaging. METHODS Smoker patients with CIS (n=16), smoker healthy controls (n=13), nonsmoker patients with CIS (n=17) and nonsmoker healthy controls (n=14) were included. Thirteen regions-of-interest including nonenhancing T1 hypointense lesion and perilesional WM, and 11 normal-appearing white matter (NAWM) regions were drawn on color-coded fractional anisotropy (FA) maps. Lesion load was determined in terms of number and volume of WM hyperintensities. RESULTS A tendency towards greater lesion load was found in smoker patients. T1 hypointense lesions and perilesional WM had reduced FA and increased mean diffusivity to a similar degree in smoker and nonsmoker CIS patients. Compared with healthy smokers, smoker CIS patients had more extensive NAWM changes shown by increased mean diffusivity. There was no relationship between diffusion metrics and clinical disability scores, duration of the disease and degree of smoking exposure. CONCLUSION Smoker patients showed a tendency towards having greater number of WM lesions and displayed significantly more extensive NAWM abnormalities. © Turkish Society of Radiology 2016.
      Keywords
      Demyelinating disease
      Diffusion tensor imaging
      Expanded disability status scale
      Fractional anisotropy
      Image analysis
      Image processing
      Mean diffusivity
      Normal appearing white matter
      Perilesional white matter
      Radiological parameters
      Regions of interest
      Smoking habit
      T1 hypointense lesion
      White matter
      Permalink
      http://hdl.handle.net/11693/37030
      Published Version (Please cite this version)
      http://dx.doi.org/10.5152/dir.2015.15415
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      • National Magnetic Resonance Research Center (UMRAM) 301
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