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      Remote-controlled release of singlet oxygen by the plasmonic heating of endoperoxide-modified gold nanorods: towards a paradigm change in photodynamic therapy

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      Author
      Kolemen, S.
      Ozdemir, T.
      Lee, D.
      Kim, G. M.
      Karatas, T.
      Yoon, J.
      Akkaya, E. U.
      Date
      2016
      Source Title
      Angewandte Chemie - International Edition
      Print ISSN
      1433-7851
      Electronic ISSN
      1521-3773
      Publisher
      Wiley-VCH Verlag
      Volume
      55
      Issue
      11
      Pages
      3606 - 3610
      Language
      English
      Type
      Article
      Item Usage Stats
      122
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      274
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      Abstract
      The photodynamic therapy of cancer is contingent upon the sustained generation of singlet oxygen in the tumor region. However, tumors of the most metastatic cancer types develop a region of severe hypoxia, which puts them beyond the reach of most therapeutic protocols. More troublesome, photodynamic action generates acute hypoxia as the process itself diminishes cellular oxygen reserves, which makes it a self-limiting method. Herein, we describe a new concept that could eventually lead to a change in the 100 year old paradigm of photodynamic therapy and potentially offer solutions to some of the lingering problems. When gold nanorods with tethered endoperoxides are irradiated at 808 nm, the endoperoxides undergo thermal cycloreversion, resulting in the generation of singlet oxygen. We demonstrate that the amount of singlet oxygen produced in this way is sufficient for triggering apoptosis in cell cultures. EPT sees the light: When gold nanorods with tethered endoperoxides are irradiated with near-infrared light, the endoperoxides undergo thermal cycloreversion, resulting in the generation of singlet oxygen. The amount of singlet oxygen generated by these nanocomposites is sufficient for triggering apoptosis in cell cultures.
      Keywords
      Cell culture
      Cell death
      Diseases
      Infrared devices
      Nanorods
      Oxygen
      Peroxides
      Photosensitizers
      Plasmons
      Remote control
      Tumors
      Endoperoxides
      Metastatic cancers
      Near infrared light
      Photodynamic action
      Plasmonic heating
      Remote controlled release
      Singlet oxygen
      Therapeutic protocols
      Photodynamic therapy
      Permalink
      http://hdl.handle.net/11693/36968
      Published Version (Please cite this version)
      http://dx.doi.org/10.1002/anie.201510064
      Collections
      • Department of Chemistry 594
      • Institute of Materials Science and Nanotechnology (UNAM) 1775
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