A bifunctional photosensitizer for enhanced fractional photodynamic therapy: singlet oxygen generation in the presence and absence of light
Author
Turan, I. S.
Yildiz, D.
Turksoy, A.
Gunaydin, G.
Akkaya, E. U.
Date
2016Source Title
Angewandte Chemie - International Edition
Print ISSN
1433-7851
Electronic ISSN
1521-3773
Publisher
Wiley-VCH Verlag
Volume
55
Issue
8
Pages
2875 - 2878
Language
English
Type
ArticleItem Usage Stats
132
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495
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Abstract
The photosensitized generation of singlet oxygen within tumor tissues during photodynamic therapy (PDT) is self-limiting, as the already low oxygen concentrations within tumors is further diminished during the process. In certain applications, to minimize photoinduced hypoxia the light is introduced intermittently (fractional PDT) to allow time for the replenishment of cellular oxygen. This condition extends the time required for effective therapy. Herein, we demonstrated that a photosensitizer with an additional 2-pyridone module for trapping singlet oxygen would be useful in fractional PDT. Thus, in the light cycle, the endoperoxide of 2-pyridone is generated along with singlet oxygen. In the dark cycle, the endoperoxide undergoes thermal cycloreversion to produce singlet oxygen, regenerating the 2-pyridone module. As a result, the photodynamic process can continue in the dark as well as in the light cycles. Cell-culture studies validated this working principle in vitro.
Keywords
Cell cultureGas generators
Oxygen
Peroxides
Photochemical reactions
Photosensitizers
Tumors
BODIPY
Cellular oxygen
Cycloreversion
Effective therapy
Photodynamic process
Photodynamic therapy (PDT)
Singlet oxygen
Singlet oxygen generation
Photodynamic therapy
Light
Photochemotherapy
Photosensitizing Agents
Proton Magnetic Resonance Spectroscopy
Singlet Oxygen
Permalink
http://hdl.handle.net/11693/36967Published Version (Please cite this version)
http://dx.doi.org/10.1002/anie.201511345Collections
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