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      • Department of Molecular Biology and Genetics
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      Mathematical modelling of bacterial quorum sensing: a review

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      Author(s)
      Pérez-Velázquez, J.
      Gölgeli, M.
      García-Contreras, R.
      Date
      2016
      Source Title
      Bulletin of Mathematical Biology
      Print ISSN
      0092-8240
      Publisher
      Springer
      Volume
      78
      Issue
      8
      Pages
      1585 - 1639
      Language
      English
      Type
      Article
      Item Usage Stats
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      1,319
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      Abstract
      Bacterial quorum sensing (QS) refers to the process of cell-to-cell bacterial communication enabled through the production and sensing of the local concentration of small molecules called autoinducers to regulate the production of gene products (e.g. enzymes or virulence factors). Through autoinducers, bacteria interact with individuals of the same species, other bacterial species, and with their host. Among QS-regulated processes mediated through autoinducers are aggregation, biofilm formation, bioluminescence, and sporulation. Autoinducers are therefore “master” regulators of bacterial lifestyles. For over 10�years, mathematical modelling of QS has sought, in parallel to experimental discoveries, to elucidate the mechanisms regulating this process. In this review, we present the progress in mathematical modelling of QS, highlighting the various theoretical approaches that have been used and discussing some of the insights that have emerged. Modelling of QS has benefited almost from the onset of the involvement of experimentalists, with many of the papers which we review, published in non-mathematical journals. This review therefore attempts to give a broad overview of the topic to the mathematical biology community, as well as the current modelling efforts and future challenges. � 2016, Society for Mathematical Biology.
      Keywords
      Antibacterial
      Autoinducers
      Bacteria
      Communication
      Mathematical modelling
      Quorum sensing
      Simulations
      Permalink
      http://hdl.handle.net/11693/36891
      Published Version (Please cite this version)
      http://dx.doi.org/10.1007/s11538-016-0160-6
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