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      Quercetin/β-cyclodextrin inclusion complex embedded nanofibres: slow release and high solubility

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      Author(s)
      Aytac Z.
      Kusku, S. I.
      Durgun, Engin
      Uyar, Tamer
      Date
      2016-04
      Source Title
      Food Chemistry
      Print ISSN
      0308-8146
      Publisher
      Elsevier
      Volume
      197
      Pages
      864 - 871
      Language
      English
      Type
      Article
      Item Usage Stats
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      605
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      Abstract
      Electrospinning of polyacrylic acid (PAA) nanofibres (NF) incorporating β-cyclodextrin inclusion complex (β-CD-IC) of quercetin (QU) was performed. Here, β-CD was used as not only the crosslinking agent for PAA nanofibres but also as a host molecule for inclusion of QU. The phase solubility test showed enhanced solubility of QU due to the inclusion complexation; in addition, the stoichiometry of QU/β-CD-IC was determined to be 1:1. Computational modelling studies confirmed that 1:1 and 1:2 complex formation are desirable; 1:1 complex formation was chosen to have higher weight loading of QU. SEM images showed that PAA/QU/β-CD-IC-NF were bead-free and uniform. XRD indicated that PAA/QU/β-CD-IC-NF were amorphous in nature without the crystalline peaks of QU. Comparative results revealed that the release profile of QU from PAA/QU/β-CD-IC-NF was much slower but greater in total than from PAA/QU/β-CD-IC-film. Moreover, high antioxidant activity and photostability of QU was achieved in PAA/QU/β-CD-IC-NF.
      Keywords
      Antioxidant activity
      Electrospinning
      Modelling
      Nanofibres
      Phase solubility
      Photostability
      Polyacrylic acid
      Quercetin
      β-Cyclodextrin
      Antioxidants
      Complexation
      Cyclodextrins
      Electrospinning
      Flavonoids
      Models
      Organic acids
      Phenols
      Solubility
      Spinning (fibers)
      Anti-oxidant activities
      Phase solubility
      Photo-stability
      Polyacrylic acids
      Quercetin
      Nanofibers
      2,2-diphenyl-1-picrylhydrazyl
      Antioxidant
      Beta cyclodextrin
      Beta cyclodextrin derivative
      Biphenyl derivative
      Drug carrier
      Nanofiber
      Picric acid
      Quercetin
      Chemical structure
      Chemistry
      Drug formulation
      Drug release
      Drug stability
      Particle size
      Scanning electron microscopy
      Solubility
      Surface property
      X ray diffraction
      Antioxidants
      Beta-Cyclodextrins
      Biphenyl Compounds
      Drug Carriers
      Drug Compounding
      Drug Liberation
      Drug Stability
      Microscopy, Electron, Scanning
      Models, Molecular
      Nanofibers
      Particle Size
      Picrates
      Quercetin
      Solubility
      Surface Properties
      X-Ray Diffraction
      Permalink
      http://hdl.handle.net/11693/36837
      Published Version (Please cite this version)
      https://doi.org/10.1016/j.foodchem.2015.11.051
      Collections
      • Institute of Materials Science and Nanotechnology (UNAM) 2260
      • Nanotechnology Research Center (NANOTAM) 1179
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