Quercetin/β-cyclodextrin inclusion complex embedded nanofibres: slow release and high solubility
Date
2016-04Source Title
Food Chemistry
Print ISSN
0308-8146
Publisher
Elsevier
Volume
197
Pages
864 - 871
Language
English
Type
ArticleItem Usage Stats
307
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605
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Abstract
Electrospinning of polyacrylic acid (PAA) nanofibres (NF) incorporating β-cyclodextrin inclusion complex (β-CD-IC) of quercetin (QU) was performed. Here, β-CD was used as not only the crosslinking agent for PAA nanofibres but also as a host molecule for inclusion of QU. The phase solubility test showed enhanced solubility of QU due to the inclusion complexation; in addition, the stoichiometry of QU/β-CD-IC was determined to be 1:1. Computational modelling studies confirmed that 1:1 and 1:2 complex formation are desirable; 1:1 complex formation was chosen to have higher weight loading of QU. SEM images showed that PAA/QU/β-CD-IC-NF were bead-free and uniform. XRD indicated that PAA/QU/β-CD-IC-NF were amorphous in nature without the crystalline peaks of QU. Comparative results revealed that the release profile of QU from PAA/QU/β-CD-IC-NF was much slower but greater in total than from PAA/QU/β-CD-IC-film. Moreover, high antioxidant activity and photostability of QU was achieved in PAA/QU/β-CD-IC-NF.
Keywords
Antioxidant activityElectrospinning
Modelling
Nanofibres
Phase solubility
Photostability
Polyacrylic acid
Quercetin
β-Cyclodextrin
Antioxidants
Complexation
Cyclodextrins
Electrospinning
Flavonoids
Models
Organic acids
Phenols
Solubility
Spinning (fibers)
Anti-oxidant activities
Phase solubility
Photo-stability
Polyacrylic acids
Quercetin
Nanofibers
2,2-diphenyl-1-picrylhydrazyl
Antioxidant
Beta cyclodextrin
Beta cyclodextrin derivative
Biphenyl derivative
Drug carrier
Nanofiber
Picric acid
Quercetin
Chemical structure
Chemistry
Drug formulation
Drug release
Drug stability
Particle size
Scanning electron microscopy
Solubility
Surface property
X ray diffraction
Antioxidants
Beta-Cyclodextrins
Biphenyl Compounds
Drug Carriers
Drug Compounding
Drug Liberation
Drug Stability
Microscopy, Electron, Scanning
Models, Molecular
Nanofibers
Particle Size
Picrates
Quercetin
Solubility
Surface Properties
X-Ray Diffraction
Permalink
http://hdl.handle.net/11693/36837Published Version (Please cite this version)
https://doi.org/10.1016/j.foodchem.2015.11.051Collections
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