Newly designed silver coated-magnetic, monodisperse polymeric microbeads as SERS substrate for low-level detection of amoxicillin
Author
Kibar, G.
Topal, A. E.
Dana, A.
Tuncel, A.
Date
2016-09Source Title
Journal of Molecular Structure
Print ISSN
0022-2860
Publisher
Elsevier
Volume
1119
Pages
133 - 138
Language
English
Type
ArticleItem Usage Stats
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Abstract
We report the preparation of silver-coated magnetic polymethacrylate core-shell nanoparticles for use in surface-enhanced Raman scattering based drug detection. Monodisperse porous poly (mono-2-(methacryloyloxy)ethyl succinate-co-glycerol dimethacrylate), poly (MMES-co-GDMA) microbeads of ca. 5 μm diameter were first synthesized through a multistage microsuspension polymerization technique to serve as a carboxyl-bearing core region. Microspheres were subsequently magnetized by the co-precipitation of ferric ions, aminated through the surface hydroxyl groups and decorated with Au nanoparticles via electrostatic attraction. An Ag shell was then formed on top of the Au layer through a seed-mediated growth process, resulting in micron-sized monodisperse microbeads that exhibit Raman enhancement effects due to the roughness of the Ag surface layer. The core-shell microspheres were used as a new substrate for the detection of amoxicillin at trace concentrations up to 10-8 M by SERS. The proposed SERS platform can be evaluated as a useful tool for the follow-up amoxicillin pollution and low-level detection of amoxicillin in aqueous media.
Keywords
Ag nanoparticlesAmoxicillin
Antibiotic
Low-level detection
Surface enhanced Raman scattering
Antibiotics
Gold
Microspheres
Nanomagnetics
Nanoparticles
Precipitation (chemical)
Raman scattering
Shells (structures)
Silver
Substrates
Ag nanoparticle
Amoxicillin
Core-shell microspheres
Core-shell nanoparticles
Electrostatic attractions
Level detections
Surface enhanced Raman Scattering (SERS)
Surface hydroxyl groups
Surface scattering