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dc.contributor.authorAytac Z.en_US
dc.contributor.authorKusku S. I.en_US
dc.contributor.authorDurgun, E.en_US
dc.contributor.authorUyar T.en_US
dc.date.accessioned2018-04-12T10:53:56Z
dc.date.available2018-04-12T10:53:56Z
dc.date.issued2016-06en_US
dc.identifier.issn0928-4931
dc.identifier.urihttp://hdl.handle.net/11693/36804
dc.description.abstractCyclodextrin-inclusion complexes (CD-ICs) possess great prominence in food and pharmaceutical industries due to their enhanced ability for stabilization of active compounds during processing, storage and usage. Here, CD-IC of gallic acid (GA) with hydroxypropyl-beta-cyclodextrin (GA/HPβCD-IC) was prepared and then incorporated into polylactic acid (PLA) nanofibers (PLA/GA/HPβCD-IC-NF) using electrospinning technique to observe the effect of CD-ICs in the release behavior of GA into three different mediums (water, 10% ethanol and 95% ethanol). The GA incorporated PLA nanofibers (PLA/GA-NFs) were served as control. Phase solubility studies showed an enhanced solubility of GA with increasing amount of HPβCD. The detailed characterization techniques (XRD, TGA and 1H-NMR) confirmed the formation of inclusion complex between GA and HPβCD. Computational modeling studies indicated that the GA made an efficient complex with HPβCD at 1:1 either in vacuum or aqueous system. SEM images revealed the bead-free and uniform morphology of PLA/GA/HPβCD-IC-NF. The release studies of GA from PLA/GA/HPβCD-IC-NF and PLA/GA-NF were carried out in water, 10% ethanol and 95% ethanol, and the findings revealed that PLA/GA/HPβCD-IC-NF has released much more amount of GA in water and 10% ethanol system when compared to PLA/GA-NF. In addition, GA was released slowly from PLA/GA/HPβCD-IC-NF into 95% ethanol when compared to PLA/GA-NF. It was also observed that electrospinning process had no negative effect on the antioxidant activity of GA when GA was incorporated in PLA nanofibers.en_US
dc.language.isoEnglishen_US
dc.source.titleMaterials Science and Engineering Cen_US
dc.relation.isversionofhttps://doi.org/10.1016/j.msec.2016.02.063en_US
dc.subjectAntioxidant activityen_US
dc.subjectElectrospinningen_US
dc.subjectGallic aciden_US
dc.subjectHydroxypropyl-beta-cyclodextrinen_US
dc.subjectPolylactic aciden_US
dc.subjectReleaseen_US
dc.subjectAntioxidantsen_US
dc.subjectCyclodextrinsen_US
dc.subjectElectrospinningen_US
dc.subjectEthanolen_US
dc.subjectFood storageen_US
dc.subjectPolyestersen_US
dc.subjectSolubilityen_US
dc.subjectSpinning (fibers)en_US
dc.subjectAnti-oxidant activitiesen_US
dc.subjectBeta-cyclodextrinen_US
dc.subjectGallic acidsen_US
dc.subjectPoly lactic aciden_US
dc.subjectReleaseen_US
dc.subjectNanofibersen_US
dc.subject2-hydroxypropyl-beta-cyclodextrinen_US
dc.subjectAntioxidanten_US
dc.subjectBeta cyclodextrin derivativeen_US
dc.subjectGallic aciden_US
dc.subjectNanofiberen_US
dc.subjectPolyesteren_US
dc.subjectPolylactideen_US
dc.subjectWateren_US
dc.subjectChemistryen_US
dc.subjectMetabolismen_US
dc.subjectScanning electron microscopyen_US
dc.subjectSolubilityen_US
dc.subjectThermogravimetryen_US
dc.subjectX ray diffractionen_US
dc.subjectAntioxidantsen_US
dc.subjectBeta-Cyclodextrinsen_US
dc.subjectGallic Aciden_US
dc.subjectMicroscopy, Electron, Scanningen_US
dc.subjectNanofibersen_US
dc.subjectPolyestersen_US
dc.subjectSolubilityen_US
dc.subjectThermogravimetryen_US
dc.subjectWateren_US
dc.subjectX-Ray Diffractionen_US
dc.titleEncapsulation of gallic acid/cyclodextrin inclusion complex in electrospun polylactic acid nanofibers: release behavior and antioxidant activity of gallic aciden_US
dc.typeArticleen_US
dc.departmentUNAM - Institute of Materials Science and Nanotechnology
dc.departmentNANOTAM - Nanotechnology Research Center
dc.citation.spage231en_US
dc.citation.epage239en_US
dc.citation.volumeNumber63en_US
dc.identifier.doi10.1016/j.msec.2016.02.063en_US
dc.publisherElsevieren_US


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