Encapsulation of gallic acid/cyclodextrin inclusion complex in electrospun polylactic acid nanofibers: release behavior and antioxidant activity of gallic acid
Date
2016-06Source Title
Materials Science and Engineering C
Print ISSN
0928-4931
Publisher
Elsevier
Volume
63
Pages
231 - 239
Language
English
Type
ArticleItem Usage Stats
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Abstract
Cyclodextrin-inclusion complexes (CD-ICs) possess great prominence in food and pharmaceutical industries due to their enhanced ability for stabilization of active compounds during processing, storage and usage. Here, CD-IC of gallic acid (GA) with hydroxypropyl-beta-cyclodextrin (GA/HPβCD-IC) was prepared and then incorporated into polylactic acid (PLA) nanofibers (PLA/GA/HPβCD-IC-NF) using electrospinning technique to observe the effect of CD-ICs in the release behavior of GA into three different mediums (water, 10% ethanol and 95% ethanol). The GA incorporated PLA nanofibers (PLA/GA-NFs) were served as control. Phase solubility studies showed an enhanced solubility of GA with increasing amount of HPβCD. The detailed characterization techniques (XRD, TGA and 1H-NMR) confirmed the formation of inclusion complex between GA and HPβCD. Computational modeling studies indicated that the GA made an efficient complex with HPβCD at 1:1 either in vacuum or aqueous system. SEM images revealed the bead-free and uniform morphology of PLA/GA/HPβCD-IC-NF. The release studies of GA from PLA/GA/HPβCD-IC-NF and PLA/GA-NF were carried out in water, 10% ethanol and 95% ethanol, and the findings revealed that PLA/GA/HPβCD-IC-NF has released much more amount of GA in water and 10% ethanol system when compared to PLA/GA-NF. In addition, GA was released slowly from PLA/GA/HPβCD-IC-NF into 95% ethanol when compared to PLA/GA-NF. It was also observed that electrospinning process had no negative effect on the antioxidant activity of GA when GA was incorporated in PLA nanofibers.
Keywords
Antioxidant activityElectrospinning
Gallic acid
Hydroxypropyl-beta-cyclodextrin
Polylactic acid
Release
Antioxidants
Cyclodextrins
Electrospinning
Ethanol
Food storage
Polyesters
Solubility
Spinning (fibers)
Anti-oxidant activities
Beta-cyclodextrin
Gallic acids
Poly lactic acid
Release
Nanofibers
2-hydroxypropyl-beta-cyclodextrin
Antioxidant
Beta cyclodextrin derivative
Gallic acid
Nanofiber
Polyester
Polylactide
Water
Chemistry
Metabolism
Scanning electron microscopy
Solubility
Thermogravimetry
X ray diffraction
Antioxidants
Beta-Cyclodextrins
Gallic Acid
Microscopy, Electron, Scanning
Nanofibers
Polyesters
Solubility
Thermogravimetry
Water
X-Ray Diffraction
Permalink
http://hdl.handle.net/11693/36804Published Version (Please cite this version)
https://doi.org/10.1016/j.msec.2016.02.063Collections
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