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      Encapsulation of gallic acid/cyclodextrin inclusion complex in electrospun polylactic acid nanofibers: release behavior and antioxidant activity of gallic acid

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      Author(s)
      Aytac Z.
      Kusku S. I.
      Durgun, Engin
      Uyar, Tamer
      Date
      2016-06
      Source Title
      Materials Science and Engineering C
      Print ISSN
      0928-4931
      Publisher
      Elsevier
      Volume
      63
      Pages
      231 - 239
      Language
      English
      Type
      Article
      Item Usage Stats
      376
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      805
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      Abstract
      Cyclodextrin-inclusion complexes (CD-ICs) possess great prominence in food and pharmaceutical industries due to their enhanced ability for stabilization of active compounds during processing, storage and usage. Here, CD-IC of gallic acid (GA) with hydroxypropyl-beta-cyclodextrin (GA/HPβCD-IC) was prepared and then incorporated into polylactic acid (PLA) nanofibers (PLA/GA/HPβCD-IC-NF) using electrospinning technique to observe the effect of CD-ICs in the release behavior of GA into three different mediums (water, 10% ethanol and 95% ethanol). The GA incorporated PLA nanofibers (PLA/GA-NFs) were served as control. Phase solubility studies showed an enhanced solubility of GA with increasing amount of HPβCD. The detailed characterization techniques (XRD, TGA and 1H-NMR) confirmed the formation of inclusion complex between GA and HPβCD. Computational modeling studies indicated that the GA made an efficient complex with HPβCD at 1:1 either in vacuum or aqueous system. SEM images revealed the bead-free and uniform morphology of PLA/GA/HPβCD-IC-NF. The release studies of GA from PLA/GA/HPβCD-IC-NF and PLA/GA-NF were carried out in water, 10% ethanol and 95% ethanol, and the findings revealed that PLA/GA/HPβCD-IC-NF has released much more amount of GA in water and 10% ethanol system when compared to PLA/GA-NF. In addition, GA was released slowly from PLA/GA/HPβCD-IC-NF into 95% ethanol when compared to PLA/GA-NF. It was also observed that electrospinning process had no negative effect on the antioxidant activity of GA when GA was incorporated in PLA nanofibers.
      Keywords
      Antioxidant activity
      Electrospinning
      Gallic acid
      Hydroxypropyl-beta-cyclodextrin
      Polylactic acid
      Release
      Antioxidants
      Cyclodextrins
      Electrospinning
      Ethanol
      Food storage
      Polyesters
      Solubility
      Spinning (fibers)
      Anti-oxidant activities
      Beta-cyclodextrin
      Gallic acids
      Poly lactic acid
      Release
      Nanofibers
      2-hydroxypropyl-beta-cyclodextrin
      Antioxidant
      Beta cyclodextrin derivative
      Gallic acid
      Nanofiber
      Polyester
      Polylactide
      Water
      Chemistry
      Metabolism
      Scanning electron microscopy
      Solubility
      Thermogravimetry
      X ray diffraction
      Antioxidants
      Beta-Cyclodextrins
      Gallic Acid
      Microscopy, Electron, Scanning
      Nanofibers
      Polyesters
      Solubility
      Thermogravimetry
      Water
      X-Ray Diffraction
      Permalink
      http://hdl.handle.net/11693/36804
      Published Version (Please cite this version)
      https://doi.org/10.1016/j.msec.2016.02.063
      Collections
      • Institute of Materials Science and Nanotechnology (UNAM) 2258
      • Nanotechnology Research Center (NANOTAM) 1179
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