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      Short-term dietary restriction in old zebrafish changes cell senescence mechanisms

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      Author
      Arslan-Ergul, A.
      Erbaba, B.
      Karoglu, E. T.
      Halim, D. O.
      Adams, M. M.
      Date
      2016-10
      Source Title
      Neuroscience
      Print ISSN
      0306-4522
      Publisher
      Elsevier
      Volume
      334
      Pages
      64 - 75
      Language
      English
      Type
      Article
      Item Usage Stats
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      Abstract
      Brain aging is marked by a decline in cognitive abilities and associated with neurodegenerative disorders. Recent studies have shown, neurogenesis continues into adulthood but is known to be decreasing during advancing age and these changes may contribute to cognitive alterations. Advances, which aim to promote better aging are of paramount importance. Dietary restriction (DR) is the only non-genetic intervention that reliably extends life- and health-span. Mechanisms of how and why DR and age affect neurogenesis are not well-understood, and have not been utilized much in the zebrafish, which has become a popular model to study brain aging and neurodegenerative disease due to widely available genetic tools. In this study we used young (8–8.5 months) and old (26–32.5 months) zebrafish as the model to investigate the effects of a short-term DR on actively proliferating cells. We successfully applied a 10-week DR to young and old fish, which resulted in a significant loss of body weight in both groups with no effect on normal age-related changes in body growth. We found that age decreased cell proliferation and increased senescence associated β-galactosidase, as well as shortened telomere lengths. In contrast, DR shortened telomere lengths only in young animals. Neither age nor DR changed the differentiation patterns of glial cells. Our results suggest that the potential effects of DR could be mediated by telomere regulation and whether these are beneficial or negative remains to be determined.
      Keywords
      Aging
      Brain
      Cell proliferation
      Dietary restriction
      Telomere
      Zebrafish
      Beta galactosidase
      Beta galactosidase
      Adult
      Age
      Animal cell
      Animal experiment
      Article
      Body growth
      Brain region
      Brain slice
      Cell differentiation
      Cell proliferation
      Controlled study
      Diet restriction
      Fish model
      Glia cell
      Nonhuman
      Priority journal
      Senescence
      Stress
      Telomere homeostasis
      Weight reduction
      Zebra fish
      Aging
      Animal
      Body weight
      Brain
      Caloric restriction
      Cell aging
      Cohort analysis
      Metabolism
      Physiology
      Randomization
      Telomere
      Time factor
      Permalink
      http://hdl.handle.net/11693/36800
      Published Version (Please cite this version)
      https://doi.org/10.1016/j.neuroscience.2016.07.033
      Collections
      • Department of Molecular Biology and Genetics 409
      • Department of Psychology 139
      • Institute of Materials Science and Nanotechnology 1580
      • Interdisciplinary Program in Neuroscience 73

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