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dc.contributor.authorMumcuoglu, M.en_US
dc.contributor.authorGurkan-Alp, A. S.en_US
dc.contributor.authorBuyukbingol, E.en_US
dc.contributor.authorCetin Atalay, R.en_US
dc.date.accessioned2018-04-12T10:52:47Z
dc.date.available2018-04-12T10:52:47Z
dc.date.issued2016en_US
dc.identifier.issn0039-128X
dc.identifier.urihttp://hdl.handle.net/11693/36772
dc.description.abstractRetinoids have been implicated as pharmacological agents for the prevention and treatment of various types of cancers, including breast cancers. We analyzed 27 newly synthesized retinoids for their bioactivity on breast, liver, and colon cancer cells. Majority of the retinoids demonstrated selective bioactivity on breast cancer cells. Retinoid 17 had a significant inhibitory activity (IC50 3.5 μM) only on breast cancer cells while no growth inhibition observed with liver and colon cancer cells. The breast cancer selective growth inhibitory action by retinoid 17 was defined as p21-dependent cell death, reminiscent of senescence, which is an indicator of targeted receptor mediated bioactivity. A comparative analysis of retinoid receptor gene expression levels in different breast cancer cells and IC50 values of 17 indicated the involvement of Retinoid X receptors in the cytotoxic bioactivity of retinoid 17 in the senescence associated cell death. Furthermore, siRNA knockdown studies with RXRγ induced decrease in cell proliferation. Therefore, we suggest that retinoid derivatives that target RXRγ, can be considered for breast cancer therapies. © 2016 Elsevier Inc. All rights reserved.en_US
dc.language.isoEnglishen_US
dc.source.titleSteroidsen_US
dc.relation.isversionofhttp://dx.doi.org/10.1016/j.steroids.2016.02.008en_US
dc.subjectBreast canceren_US
dc.subjectCytotoxicityen_US
dc.subjectRetinoiden_US
dc.subjectRXRen_US
dc.subjectSenescenceen_US
dc.titleRetinoid N-(1H-benzo[d]imidazol-2-yl)-5,5,8,8-tetramethyl-5,6,7, 8-tetrahydronaphthalene-2-carboxamide induces p21-dependent senescence in breast cancer cellsen_US
dc.typeArticleen_US
dc.departmentDepartment of Molecular Biology and Genetics
dc.citation.spage31en_US
dc.citation.epage38en_US
dc.citation.volumeNumber108en_US
dc.identifier.doi10.1016/j.steroids.2016.02.008en_US
dc.publisherElsevieren_US


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