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dc.contributor.authorMalekghasemi, S.en_US
dc.contributor.authorKahveci, E.en_US
dc.contributor.authorDuman, M.en_US
dc.date.accessioned2018-04-12T10:52:40Z
dc.date.available2018-04-12T10:52:40Z
dc.date.issued2016en_US
dc.identifier.issn0039-9140
dc.identifier.urihttp://hdl.handle.net/11693/36769
dc.description.abstractA major application of microfluidic paper-based analytical devices (µPADs) includes the field of point-of-care (POC) diagnostics. It is important for POC diagnostics to possess properties such as ease-of-use and low cost. However, µPADs need multiple instruments and fabrication steps. In this study, two different chemicals (Hexamethyldisilazane and Tetra-ethylorthosilicate) were used, and three different methods (heating, plasma treatment, and microwave irradiation) were compared to develop µPADs. Additionally, an inkjet-printing technique was used for generating a hydrophilic channel and printing certain chemical agents on different regions of a modified filter paper. A rapid and effective fabrication method to develop µPADs within 10 min was introduced using an inkjet-printing technique in conjunction with a microwave irradiation method. Environmental scanning electron microscope (ESEM) and x-ray photoelectron spectroscopy (XPS) were used for morphology characterization and determining the surface chemical compositions of the modified filter paper, respectively. Contact angle measurements were used to fulfill the hydrophobicity of the treated filter paper. The highest contact angle value (141°±1) was obtained using the microwave irradiation method over a period of 7 min, when the filter paper was modified by TEOS. Furthermore, by using this method, the XPS results of TEOS-modified filter paper revealed Si2p (23%) and Si-O bounds (81.55%) indicating the presence of Si–O–Si bridges and Si(OEt) groups, respectively. The ESEM results revealed changes in the porous structures of the papers and decreases in the pore sizes. Washburn assay measurements tested the efficiency of the generated hydrophilic channels in which similar water penetration rates were observed in the TEOS-modified filter paper and unmodified (plain) filter paper. The validation of the developed µPADs was performed by utilizing the rapid urease test as a model test system. The detection limit of the developed µPADs was measured as 1 unit ml−1 urease enzyme in detection zones within a period of 3 min. The study findings suggested that a combination of microwave irradiation with inkjet-printing technique could improve the fabrication method of µPADs, enabling faster production of µPADs that are easy to use and cost-effective with long shelf lives.en_US
dc.language.isoEnglishen_US
dc.source.titleTalantaen_US
dc.relation.isversionofhttp://dx.doi.org/10.1016/j.talanta.2016.06.040en_US
dc.subjectCellulose fibersen_US
dc.subjectInk-jet printingen_US
dc.subjectMicrofluidic paper based analytical deviceen_US
dc.subjectMicrowave irradiationen_US
dc.subjectPoint of careen_US
dc.subjectSilylationen_US
dc.subjectAnalytic equipmenten_US
dc.subjectContact angleen_US
dc.subjectCost effectivenessen_US
dc.subjectFabricationen_US
dc.subjectFighter aircraften_US
dc.subjectHydrophilicityen_US
dc.subjectInken_US
dc.subjectIrradiationen_US
dc.subjectMicrofluidicsen_US
dc.subjectMicrowave irradiationen_US
dc.subjectMicrowavesen_US
dc.subjectPaperen_US
dc.subjectPlasma applicationsen_US
dc.subjectPore sizeen_US
dc.subjectScanning electron microscopyen_US
dc.subjectSiliconen_US
dc.subjectX ray photoelectron spectroscopyen_US
dc.subjectCellulose fiberen_US
dc.subjectEnvironmental scanning electron microscopesen_US
dc.subjectHydrophilic channelsen_US
dc.subjectMorphology characterizationsen_US
dc.subjectPaper-based analytical devicesen_US
dc.subjectPoint of careen_US
dc.subjectSilylationsen_US
dc.subjectSurface chemical compositionen_US
dc.subjectInk jet printingen_US
dc.subjectCellulose fibersen_US
dc.subjectFilter papersen_US
dc.subjectInk jet printingen_US
dc.subjectRadiation effectsen_US
dc.titleRapid and alternative fabrication method for microfluidic paper based analytical devicesen_US
dc.typeArticleen_US
dc.departmentInstitute of Materials Science and Nanotechnology (UNAM)en_US
dc.citation.spage401en_US
dc.citation.epage411en_US
dc.citation.volumeNumber159en_US
dc.identifier.doi10.1016/j.talanta.2016.06.040en_US
dc.publisherElsevier B.V.en_US
dc.identifier.eissn1873-3573en_US


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