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      Fast-dissolving, prolonged release, and antibacterial cyclodextrin/limonene-inclusion complex nanofibrous webs via polymer-free electrospinning

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      Author(s)
      Aytac Z.
      Yildiz, Z. I.
      Kayaci-Senirmak, F.
      S. Keskin, N. O.
      Kusku, S. I.
      Durgun, Engin
      Tekinay, T.
      Uyar, Tamer
      Date
      2016
      Source Title
      Journal of Agricultural and Food Chemistry
      Print ISSN
      0021-8561
      Publisher
      American Chemical Society
      Volume
      64
      Issue
      39
      Pages
      7325 - 7334
      Language
      English
      Type
      Article
      Item Usage Stats
      220
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      246
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      Abstract
      We have proposed a new strategy for preparing free-standing nanofibrous webs from an inclusion complex (IC) of a well-known flavor/fragrance compound (limonene) with three modified cyclodextrins (HPβCD, MβCD, and HPγCD) via electrospinning (CD/limonene-IC-NFs) without using a polymeric matrix. The experimental and computational modeling studies proved that the stoichiometry of the complexes was 1:1 for CD/limonene systems. MβCD/limonene-IC-NF released much more limonene at 37, 50, and 75 °C than HPβCD/limonene-IC-NF and HPγCD/limonene-IC-NF because of the greater amount of preserved limonene. Moreover, MβCD/limonene-IC-NF has released only 25% (w/w) of its limonene, whereas HPβCD/limonene-IC-NF and HPγCD/limonene-IC-NF released 51 and 88% (w/w) of their limonene in 100 days, respectively. CD/limonene-IC-NFs exhibited high antibacterial activity against E. coli and S. aureus. The water solubility of limonene increased significantly and CD/limonene-IC-NFs were dissolved in water in a few seconds. In brief, CD/limonene-IC-NFs with fast-dissolving character enhanced the thermal stability and prolonged the shelf life along with antibacterial properties could be quite applicable in food and oral care applications.
      Keywords
      Antibacterial activity
      Computational modeling
      Electrospinning
      Essential oil
      Modified cyclodextrins
      Computation theory
      Cyclodextrins
      Electrospinning
      Escherichia coli
      Essential oils
      Flavor compounds
      Monoterpenes
      Nanofibers
      Oils and fats
      Polymers
      Spinning (fibers)
      Anti-bacterial activity
      Antibacterial properties
      Computational model
      Inclusion complex
      Modified cyclodextrins
      Polymeric matrices
      Prolonged release
      Water solubilities
      Dissolution
      Antiinfective agent
      Cyclodextrin
      Cyclohexene derivative
      Drug carrier
      Essential oil
      Limonene
      Nanofiber
      Terpene
      Chemistry
      Drug effects
      Drug release
      Drug stability
      Escherichia coli
      Molecular computer
      Nuclear magnetic resonance spectroscopy
      Particle size
      Scanning electron microscopy
      Solubility
      Staphylococcus aureus
      Thermogravimetry
      X ray crystallography
      Anti-Bacterial Agents
      Computers, Molecular
      Crystallography, X-Ray
      Cyclodextrins
      Cyclohexenes
      Drug Carriers
      Drug Liberation
      Drug Stability
      Escherichia coli
      Magnetic Resonance Spectroscopy
      Microscopy, Electron, Scanning
      Nanofibers
      Oils, Volatile
      Particle Size
      Solubility
      Staphylococcus aureus
      Terpenes
      Thermogravimetry
      Permalink
      http://hdl.handle.net/11693/36745
      Published Version (Please cite this version)
      https://doi.org/10.1021/acs.jafc.6b02632
      Collections
      • Institute of Materials Science and Nanotechnology (UNAM) 1930
      • Nanotechnology Research Center (NANOTAM) 1063
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