Fast-dissolving, prolonged release, and antibacterial cyclodextrin/limonene-inclusion complex nanofibrous webs via polymer-free electrospinning
Author(s)
Date
2016Source Title
Journal of Agricultural and Food Chemistry
Print ISSN
0021-8561
Publisher
American Chemical Society
Volume
64
Issue
39
Pages
7325 - 7334
Language
English
Type
ArticleItem Usage Stats
220
views
views
246
downloads
downloads
Abstract
We have proposed a new strategy for preparing free-standing nanofibrous webs from an inclusion complex (IC) of a well-known flavor/fragrance compound (limonene) with three modified cyclodextrins (HPβCD, MβCD, and HPγCD) via electrospinning (CD/limonene-IC-NFs) without using a polymeric matrix. The experimental and computational modeling studies proved that the stoichiometry of the complexes was 1:1 for CD/limonene systems. MβCD/limonene-IC-NF released much more limonene at 37, 50, and 75 °C than HPβCD/limonene-IC-NF and HPγCD/limonene-IC-NF because of the greater amount of preserved limonene. Moreover, MβCD/limonene-IC-NF has released only 25% (w/w) of its limonene, whereas HPβCD/limonene-IC-NF and HPγCD/limonene-IC-NF released 51 and 88% (w/w) of their limonene in 100 days, respectively. CD/limonene-IC-NFs exhibited high antibacterial activity against E. coli and S. aureus. The water solubility of limonene increased significantly and CD/limonene-IC-NFs were dissolved in water in a few seconds. In brief, CD/limonene-IC-NFs with fast-dissolving character enhanced the thermal stability and prolonged the shelf life along with antibacterial properties could be quite applicable in food and oral care applications.
Keywords
Antibacterial activityComputational modeling
Electrospinning
Essential oil
Modified cyclodextrins
Computation theory
Cyclodextrins
Electrospinning
Escherichia coli
Essential oils
Flavor compounds
Monoterpenes
Nanofibers
Oils and fats
Polymers
Spinning (fibers)
Anti-bacterial activity
Antibacterial properties
Computational model
Inclusion complex
Modified cyclodextrins
Polymeric matrices
Prolonged release
Water solubilities
Dissolution
Antiinfective agent
Cyclodextrin
Cyclohexene derivative
Drug carrier
Essential oil
Limonene
Nanofiber
Terpene
Chemistry
Drug effects
Drug release
Drug stability
Escherichia coli
Molecular computer
Nuclear magnetic resonance spectroscopy
Particle size
Scanning electron microscopy
Solubility
Staphylococcus aureus
Thermogravimetry
X ray crystallography
Anti-Bacterial Agents
Computers, Molecular
Crystallography, X-Ray
Cyclodextrins
Cyclohexenes
Drug Carriers
Drug Liberation
Drug Stability
Escherichia coli
Magnetic Resonance Spectroscopy
Microscopy, Electron, Scanning
Nanofibers
Oils, Volatile
Particle Size
Solubility
Staphylococcus aureus
Terpenes
Thermogravimetry
Permalink
http://hdl.handle.net/11693/36745Published Version (Please cite this version)
https://doi.org/10.1021/acs.jafc.6b02632Collections
Related items
Showing items related by title, author, creator and subject.
-
Antibacterial electrospun zein nanofibrous web encapsulating thymol/cyclodextrin-inclusion complex for food packaging
Aytac Z.; Ipek, S.; Durgun, Engin; Tekinay, T.; Uyar, Tamer (Elsevier, 2017-10)Thymol (THY)/γ-Cyclodextrin(γ-CD) inclusion complex (IC) encapsulated electrospun zein nanofibrous webs (zein-THY/γ-CD-IC-NF) were fabricated as a food packaging material. The formation of THY/γ-CD-IC (1:1 and 2:1) was ... -
Antibacterial electrospun nanofibers from triclosan/cyclodextrin inclusion complexes
Celebioglu A.; Umu, O. C. O.; Tekinay, T.; Uyar, Tamer (Elsevier, 2014)The electrospinning of nanofibers (NF) from cyclodextrin inclusion complexes (CD-IC) with an antibacterial agent (triclosan) was achieved without using any carrier polymeric matrix. Polymer-free triclosan/CD-IC NF were ... -
Cyclodextrin functionalized nanofibers via electrospinning
Çelebioğlu, Aslı (Bilkent University, 2014)Electrospinning is a commonly studied and widely applied technique for generating nanofibers, with a diameter ranging from several tens of nanometers to a few micrometers. The low-cost, simple set-up, relatively high ...