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      Angiogenic peptide nanofibers improve wound healing in STZ-induced diabetic rats

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      Author(s)
      Senturk, B.
      Mercan, S.
      Delibasi, T.
      Güler, Mustafa O.
      Tekinay, A. B.
      Date
      2016-06
      Source Title
      ACS Biomaterials Science and Engineering
      Print ISSN
      2373-9878
      Publisher
      American Chemical Society
      Volume
      2
      Issue
      7
      Pages
      1180 - 1189
      Language
      English
      Type
      Article
      Item Usage Stats
      213
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      230
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      Abstract
      Low expressions of angiogenic growth factors delay the healing of diabetic wounds by interfering with the process of blood vessel formation. Heparin mimetic peptide nanofibers can bind to and enhance production and activity of major angiogenic growth factors, including VEGF. In this study, we showed that heparin mimetic peptide nanofibers can serve as angiogenic scaffolds that allow slow release of growth factors and protect them from degradation, providing a new therapeutic way to accelerate healing of diabetic wounds. We treated wounds in STZ-induced diabetic rats with heparin mimetic peptide nanofibers and studied repair of full-thickness diabetic skin wounds. Wound recovery was quantified by analyses of re-epithelialization, granulation tissue formation and blood vessel density, as well as VEGF and inflammatory response measurements. Wound closure and granulation tissue formation were found to be significantly accelerated in heparin mimetic gel treated groups. In addition, blood vessel counts and the expressions of alpha smooth muscle actin and VEGF were significantly higher in bioactive gel treated animals. These results strongly suggest that angiogenic heparin mimetic nanofiber therapy can be used to support the impaired healing process in diabetic wounds.
      Keywords
      Angiogenesis
      Diabetic wound healing
      Heparin mimetic
      Peptide amphiphiles
      VEGF expression
      Alpha smooth muscle actin
      Angiogenesis inhibitor
      Growth factor
      Heparin derivative
      Heparin mimetic peptide
      Nanofiber
      Streptozocin
      Unclassified drug
      Vasculotropin
      Animal experiment
      Animal tissue
      Antiangiogenic therapy
      Article
      Blood vessel
      Capillary density
      Controlled study
      Diabetic wound
      Diabetic wound
      Epithelization
      Gel
      Granulation tissue
      Inflammation
      Male
      Nonhuman
      Priority journal
      Protein degradation
      Protein expression
      Rat
      Skin
      Skinfold thickness
      Streptozotocin-induced diabetes mellitus
      Wound
      Wound closure
      Wound healing
      Permalink
      http://hdl.handle.net/11693/36723
      Published Version (Please cite this version)
      https://doi.org/10.1021/acsbiomaterials.6b00238
      Collections
      • Institute of Materials Science and Nanotechnology (UNAM) 2098
      • Nanotechnology Research Center (NANOTAM) 1125
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