Angiogenic peptide nanofibers improve wound healing in STZ-induced diabetic rats
Guler, M. O.
Tekinay, A. B.
ACS Biomaterials Science and Engineering
American Chemical Society
1180 - 1189
Item Usage Stats
MetadataShow full item record
Low expressions of angiogenic growth factors delay the healing of diabetic wounds by interfering with the process of blood vessel formation. Heparin mimetic peptide nanofibers can bind to and enhance production and activity of major angiogenic growth factors, including VEGF. In this study, we showed that heparin mimetic peptide nanofibers can serve as angiogenic scaffolds that allow slow release of growth factors and protect them from degradation, providing a new therapeutic way to accelerate healing of diabetic wounds. We treated wounds in STZ-induced diabetic rats with heparin mimetic peptide nanofibers and studied repair of full-thickness diabetic skin wounds. Wound recovery was quantified by analyses of re-epithelialization, granulation tissue formation and blood vessel density, as well as VEGF and inflammatory response measurements. Wound closure and granulation tissue formation were found to be significantly accelerated in heparin mimetic gel treated groups. In addition, blood vessel counts and the expressions of alpha smooth muscle actin and VEGF were significantly higher in bioactive gel treated animals. These results strongly suggest that angiogenic heparin mimetic nanofiber therapy can be used to support the impaired healing process in diabetic wounds.
Diabetic wound healing
Alpha smooth muscle actin
Heparin mimetic peptide
Streptozotocin-induced diabetes mellitus
Published Version (Please cite this version)https://doi.org/10.1021/acsbiomaterials.6b00238
Showing items related by title, author, creator and subject.
Şentürk, Berna (Bilkent University, 2016-06)Angiogenesis is important in many diseases, such as diabetic wound healing, cancer and corneal neovascularization. Angiogenesis can be induced or inhibited by complex biological systems. Mimicking the complexity in natural ...
Uzunalli, G.; Mammadov R.; Yesildal, F.; Alhan, D.; Ozturk, S.; Ozgurtas, T.; Guler, M. O.; Tekinay, A. B. (American Chemical Society, 2017)Wound repair in adult mammals typically ends with the formation of a scar, which prevents full restoration of the function of the healthy tissue, although most of the wounded skin heals. Rapid and functional recovery of ...
Yergoz, F.; Hastar, N.; Cimenci, C. E.; Ozkan, A. D.; Guler, M. O.; Tekinay, A. B.; Tekinay, T.; Guler, M. O. (Elsevier Ltd, 2017)Burn injuries are one of the most common types of trauma worldwide, and their unique physiology requires the development of specialized therapeutic materials for their treatment. Here, we report the use of synthetic, ...