• About
  • Policies
  • What is open access
  • Library
  • Contact
Advanced search
      View Item 
      •   BUIR Home
      • Scholarly Publications
      • Institute of Materials Science and Nanotechnology (UNAM)
      • View Item
      •   BUIR Home
      • Scholarly Publications
      • Institute of Materials Science and Nanotechnology (UNAM)
      • View Item
      JavaScript is disabled for your browser. Some features of this site may not work without it.

      Cytotoxicity of multifunctional surfactant containing capped mesoporous silica nanoparticles

      Thumbnail
      View / Download
      1.2 Mb
      Author(s)
      Yildirim, A.
      Turkaydin, M.
      Garipcan, B.
      Bayındır, Mehmet
      Date
      2016
      Source Title
      RSC Advances
      Print ISSN
      2046-2069
      Publisher
      Royal Society of Chemistry
      Volume
      6
      Issue
      38
      Pages
      32060 - 32069
      Language
      English
      Type
      Article
      Item Usage Stats
      138
      views
      106
      downloads
      Abstract
      This paper reports the synthesis of silica capped surfactant (cetyltrimethylammonium bromide; CTAB) and dye (Rose Bengal; RB) containing mesoporous silica nanoparticles (MSNs). Capping the pores of the surfactant containing MSNs with a thin silica layer decreased the immediate surfactant originated cytotoxicity of these particles without affecting their long term (3 days) cytotoxicity. Also, the silica capping process almost completely prevented the hemolytic activity of the surfactant containing MSNs. In addition, improved uptake of silica capped MSNs compared to the uncapped particles by cancer cells was demonstrated. The delayed cytotoxicity, low hemolytic activity, and better cellular uptake of the silica capped MSNs make them promising for the development of safe (i.e. with fewer side effects) yet efficient theranostic agents. These nanocarriers may release the loaded cytotoxic molecules (CTAB) mostly after being accumulated in the tumor site and cause so minimal damage to the normal tissues and blood components. In addition, the nanoscale confinement of RB molecules inside the pores of MSNs makes the particles brightly fluorescent. Furthermore, it was demonstrated that due to the singlet oxygen generation capability of the RB dye the silica capped MSNs can be also used for photodynamic therapy of cancer. © 2016 The Royal Society of Chemistry.
      Keywords
      Diseases
      Gas generators
      Molecules
      Nanoparticles
      Photodynamic therapy
      Silica
      Surface active agents
      Synthesis (chemical)
      Capped mesoporous silica
      Cetyl trimethyl ammonium bromides
      Hemolytic activity
      Low hemolytic activities
      Mesoporous silica nanoparticles
      Nano-scale confinements
      Singlet oxygen generation
      Theranostic agents
      Cytotoxicity
      Permalink
      http://hdl.handle.net/11693/36688
      Published Version (Please cite this version)
      https://doi.org/10.1039/c5ra21722a
      Collections
      • Institute of Materials Science and Nanotechnology (UNAM) 1930
      • Nanotechnology Research Center (NANOTAM) 1063
      Show full item record

      Browse

      All of BUIRCommunities & CollectionsTitlesAuthorsAdvisorsBy Issue DateKeywordsTypeDepartmentsThis CollectionTitlesAuthorsAdvisorsBy Issue DateKeywordsTypeDepartments

      My Account

      LoginRegister

      Statistics

      View Usage StatisticsView Google Analytics Statistics

      Bilkent University

      If you have trouble accessing this page and need to request an alternate format, contact the site administrator. Phone: (312) 290 1771
      © Bilkent University - Library IT

      Contact Us | Send Feedback | Off-Campus Access | Admin | Privacy