Show simple item record

dc.contributor.authorDurhan, G.en_US
dc.contributor.authorDiker, S.en_US
dc.contributor.authorHas, A. C.en_US
dc.contributor.authorKarakaya, J.en_US
dc.contributor.authorKurne, A. T.en_US
dc.contributor.authorKarabudak, R.en_US
dc.contributor.authorOguz, K. K.en_US
dc.date.accessioned2018-04-12T10:45:38Z
dc.date.available2018-04-12T10:45:38Z
dc.date.issued2016en_US
dc.identifier.issn0020-7454
dc.identifier.urihttp://hdl.handle.net/11693/36598
dc.description.abstractPurpose: Smoking has been associated with an increased risk of developing multiple sclerosis, disease progression and clinical disability. We detected the effects of smoking on regional brain volumes and lesion load in patients with clinically isolated syndrome using quantitative magnetic resonance imaging. Materials and Methods: Smoker patients (n = 16), smoker healthy controls (n = 13), non-smoker patients (n = 17) and non-smoker healthy controls (n = 14) underwent magnetic resonance imaging and neocortical volumes were measured. Lesion load was calculated in terms of number and volume of white matter hyperintensities. Results: Smoking was associated with increased gray matter volumes in several regions of the brain. A tendency towards greater lesion load in smoker patients was found. Smoking duration was significantly negatively correlated with intracranial volume and left hemisphere cortical gray matter volume. There was no relationship between regional brain volumes and clinical disability scores, lesion load duration of the disease and degree of smoking exposure. Conclusions: Clinically isolated syndrome related regional brain atrophy might vary in extent and severity with smoking. Despite increased lesion load, less cortical and deep gray matter damage with a possible neuroprotective effect occurs in smoking. © 2015 Taylor and Francis.en_US
dc.language.isoEnglishen_US
dc.source.titleInternational Journal of Neuroscienceen_US
dc.relation.isversionofhttp://dx.doi.org/10.3109/00207454.2015.1073727en_US
dc.subjectBrain volumeen_US
dc.subjectCigarette smokingen_US
dc.subjectClinically isolated syndromeen_US
dc.titleAssessment of the effect of cigarette smoking on regional brain volumes and lesion load in patients with clinically isolated syndromeen_US
dc.typeArticleen_US
dc.departmentNational Magnetic Resonance Research Center (UMRAM)en_US
dc.citation.spage805en_US
dc.citation.epage811en_US
dc.citation.volumeNumber126en_US
dc.citation.issueNumber9en_US
dc.identifier.doi10.3109/00207454.2015.1073727en_US
dc.publisherTaylor and Francis Ltden_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record