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      Progesterone change in the late follicular phase affects pregnancy rates both agonist and antagonist protocols in normoresponders: a case-controlled study in ICSI cycles

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      Author(s)
      Demir, B.
      Kahyaoglu, I.
      Guvenir, A.
      Yerebasmaz, N.
      Altinbas, S.
      Dilbaz, B.
      Dilbaz, S.
      Mollamahmutoglu, L.
      Date
      2016
      Source Title
      Gynecological Endocrinology
      Print ISSN
      0951-3590
      Electronic ISSN
      1473-0766
      Publisher
      Taylor & Francis
      Volume
      32
      Issue
      5
      Pages
      361 - 365
      Language
      English
      Type
      Article
      Item Usage Stats
      183
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      128
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      Abstract
      Objective: The aim of the presented study is to investigate the impact of progesterone change in the late follicular phase on the pregnancy rates of both agonist and antagonist protocols in normoresponders.Study design: A total of 201 normoresponder patients, who underwent embryo transfer were consecutively selected. 118 patients were stimulated using a long luteal GnRH agonist protocol and 83 using a flexible antagonist protocol. The level of change in late follicular phase progesterone was calculated according to the progesterone levels on the hCG day and pre-hCG day (1 or 2 days prior to hCG day) measurement.Results: Clinical pregnancy rates were comparable between long luteal and antagonist group (35.6 and 41%, respectively). The incidence of progesterone elevation on the hCG day was 11% in long luteal and 18% in antagonist group (p = 0.16). In pregnant cycles, p levels both on the hCG day and pre-hCG day measurement were significantly higher in antagonist than agonist cycles (p = 0.029, p = 0.038, respectively). The change of p level was statistically significant in non-pregnant cycles both for the agonist (-0.17 ± 0.07; 95% CI: -0.29 to -0.37) and antagonist groups (-0.18 ± 0.07; 95%CI: -0.31 to -0.04).Conclusions: Late follicular phase progesterone levels were stable during the cycles of pregnant patients irrespective of the protocols and were shown to be higher in pregnant patients in antagonist cycles when compared to agonist cycles.
      Keywords
      GnRH antagonist
      In-vitro fertilization
      Intracytoplasmic sperm injection
      Progesterone
      Chorionic gonadotropin
      Estradiol
      Follitropin
      Gonadorelin agonist
      Luteinizing hormone
      Progesterone
      Cetrorelix
      Follitropin
      Ganirelix
      Gonadorelin
      Hormone antagonist
      Leuprorelin
      Luteinizing hormone
      Progesterone
      Adult
      Controlled study
      Embryo transfer
      Female
      Fertilization in vitro
      Follicular phase
      Human
      Incidence
      Intracytoplasmic sperm injection
      Luteal phase
      Major clinical study
      Pregnancy rate
      Priority journal
      Progesterone blood level
      Analogs and derivatives
      Antagonists and inhibitors
      Blood
      Case control study
      Follicular phase
      Ovulation induction
      Pregnancy
      Procedures
      Case-control studies
      Embryo transfer
      Female
      Follicle stimulating hormone
      Follicular phase
      Gonadotropin-releasing hormone
      Hormone antagonists
      Humans
      Leuprolide
      Luteinizing Hormone
      Ovulation Induction
      Pregnancy
      Pregnancy Rate
      Progesterone
      Sperm Injections
      Intracytoplasmic
      Permalink
      http://hdl.handle.net/11693/36587
      Published Version (Please cite this version)
      http://dx.doi.org/10.3109/09513590.2015.1121226
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      • Department of Computer Engineering 1510
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