Progesterone change in the late follicular phase affects pregnancy rates both agonist and antagonist protocols in normoresponders: a case-controlled study in ICSI cycles
Author(s)
Date
2016Source Title
Gynecological Endocrinology
Print ISSN
0951-3590
Electronic ISSN
1473-0766
Publisher
Taylor & Francis
Volume
32
Issue
5
Pages
361 - 365
Language
English
Type
ArticleItem Usage Stats
183
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128
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Abstract
Objective: The aim of the presented study is to investigate the impact of progesterone change in the late follicular phase on the pregnancy rates of both agonist and antagonist protocols in normoresponders.Study design: A total of 201 normoresponder patients, who underwent embryo transfer were consecutively selected. 118 patients were stimulated using a long luteal GnRH agonist protocol and 83 using a flexible antagonist protocol. The level of change in late follicular phase progesterone was calculated according to the progesterone levels on the hCG day and pre-hCG day (1 or 2 days prior to hCG day) measurement.Results: Clinical pregnancy rates were comparable between long luteal and antagonist group (35.6 and 41%, respectively). The incidence of progesterone elevation on the hCG day was 11% in long luteal and 18% in antagonist group (p = 0.16). In pregnant cycles, p levels both on the hCG day and pre-hCG day measurement were significantly higher in antagonist than agonist cycles (p = 0.029, p = 0.038, respectively). The change of p level was statistically significant in non-pregnant cycles both for the agonist (-0.17 ± 0.07; 95% CI: -0.29 to -0.37) and antagonist groups (-0.18 ± 0.07; 95%CI: -0.31 to -0.04).Conclusions: Late follicular phase progesterone levels were stable during the cycles of pregnant patients irrespective of the protocols and were shown to be higher in pregnant patients in antagonist cycles when compared to agonist cycles.
Keywords
GnRH antagonistIn-vitro fertilization
Intracytoplasmic sperm injection
Progesterone
Chorionic gonadotropin
Estradiol
Follitropin
Gonadorelin agonist
Luteinizing hormone
Progesterone
Cetrorelix
Follitropin
Ganirelix
Gonadorelin
Hormone antagonist
Leuprorelin
Luteinizing hormone
Progesterone
Adult
Controlled study
Embryo transfer
Female
Fertilization in vitro
Follicular phase
Human
Incidence
Intracytoplasmic sperm injection
Luteal phase
Major clinical study
Pregnancy rate
Priority journal
Progesterone blood level
Analogs and derivatives
Antagonists and inhibitors
Blood
Case control study
Follicular phase
Ovulation induction
Pregnancy
Procedures
Case-control studies
Embryo transfer
Female
Follicle stimulating hormone
Follicular phase
Gonadotropin-releasing hormone
Hormone antagonists
Humans
Leuprolide
Luteinizing Hormone
Ovulation Induction
Pregnancy
Pregnancy Rate
Progesterone
Sperm Injections
Intracytoplasmic
Permalink
http://hdl.handle.net/11693/36587Published Version (Please cite this version)
http://dx.doi.org/10.3109/09513590.2015.1121226Collections
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