Surface-modified bacterial nanofibrillar PHB scaffolds for bladder tissue repair
Mizrak, A. K.
Denkbaş, E. B.
Artificial Cells, Nanomedicine and Biotechnology
Taylor and Francis Ltd.
74 - 82
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The aim of the study is in vitro investigation of the feasibility of surface-modified bacterial nanofibrous poly [(R)-3-hydroxybutyrate] (PHB) graft for bladder reconstruction. In this study, the surface of electrospun bacterial PHB was modified with PEG- or EDA via radio frequency glow discharge method. After plasma modification, contact angle of EDA-modified PHB scaffolds decreased from 110 ï¿½ 1.50 to 23 ï¿½ 0.5 degree. Interestingly, less calcium oxalate stone deposition was observed on modified PHB scaffolds compared to that of non-modified group. Results of this study show that surface-modified scaffolds not only inhibited calcium oxalate growth but also enhanced the uroepithelial cell viability and proliferation.
Calcium oxalate stones
Poly [(R)-3-hydroxybutyrate] (PHB)
Radio frequency glow discharge
3 hydroxybutyric acid
Poly [(r) 3 hydroxybutyrate]
Calcium oxalate stone
In vitro study
Isolation and purification
Published Version (Please cite this version)http://dx.doi.org/10.3109/21691401.2014.913053
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