• About
  • Policies
  • What is open access
  • Library
  • Contact
Advanced search
      View Item 
      •   BUIR Home
      • Scholarly Publications
      • Institute of Materials Science and Nanotechnology (UNAM)
      • View Item
      •   BUIR Home
      • Scholarly Publications
      • Institute of Materials Science and Nanotechnology (UNAM)
      • View Item
      JavaScript is disabled for your browser. Some features of this site may not work without it.

      Nanoengineering hybrid supramolecular multilayered biomaterials using polysaccharides and self-assembling peptide amphiphiles

      Thumbnail
      Embargo Lift Date: 2018-05-04
      View / Download
      5.6 Mb
      Author(s)
      Borges, J.
      Sousa, M. P.
      Cinar, G.
      Caridade, S. G.
      Güler, Mustafa O.
      Mano, J. F.
      Date
      2017
      Source Title
      Advanced Functional Materials
      Print ISSN
      1616-301X
      Electronic ISSN
      1616-3028
      Publisher
      Wiley-VCH Verlag
      Volume
      27
      Issue
      17
      Pages
      1605122-1 - 1605122-14
      Language
      English
      Type
      Article
      Item Usage Stats
      265
      views
      479
      downloads
      Abstract
      Developing complex supramolecular biomaterials through highly dynamic and reversible noncovalent interactions has attracted great attention from the scientific community aiming key biomedical and biotechnological applications, including tissue engineering, regenerative medicine, or drug delivery. In this study, the authors report the fabrication of hybrid supramolecular multilayered biomaterials, comprising high-molecular-weight biopolymers and oppositely charged low-molecular-weight peptide amphiphiles (PAs), through combination of self-assembly and electrostatically driven layer-by-layer (LbL) assembly approach. Alginate, an anionic polysaccharide, is used to trigger the self-assembling capability of positively charged PA and formation of 1D nanofiber networks. The LbL technology is further used to fabricate supramolecular multilayered biomaterials by repeating the alternate deposition of both molecules. The fabrication process is monitored by quartz crystal microbalance, revealing that both materials can be successfully combined to conceive stable supramolecular systems. The morphological properties of the systems are studied by advanced microscopy techniques, revealing the nanostructured dimensions and 1D nanofibrous network of the assembly formed by the two molecules. Enhanced C2C12 cell adhesion, proliferation, and differentiation are observed on nanostructures having PA as outermost layer. Such supramolecular biomaterials demonstrate to be innovative matrices for cell culture and hold great potential to be used in the near future as promising biomimetic supramolecular nanoplatforms for practical applications.
      Keywords
      Layer-by-layer assembly
      Peptide amphiphiles
      Polysaccharides
      Self-assembly
      Supramolecular nanostructured multilayered biomaterials
      Alginate
      Amphiphiles
      Biomimetics
      Biopolymers
      Cell adhesion
      Cell culture
      Deposition
      Ions
      Molecular weight
      Molecules
      Nanofibers
      Nanostructures
      Optical microscopy
      Peptides
      Polysaccharides
      Self assembly
      Tissue engineering
      Biotechnological applications
      Electrostatically driven
      Layer-by-layer assemblies
      Low-molecular-weight peptides
      Morphological properties
      Multi-layered
      Peptide amphiphiles
      Self-assembling peptides
      Supramolecular chemistry
      Permalink
      http://hdl.handle.net/11693/36425
      Published Version (Please cite this version)
      http://dx.doi.org/10.1002/adfm.201605122
      Collections
      • Institute of Materials Science and Nanotechnology (UNAM) 2260
      Show full item record

      Related items

      Showing items related by title, author, creator and subject.

      • Thumbnail

        Self-assembled peptide nanofiber templated ALD growth of TiO2 and ZnO semiconductor nanonetworks 

        Garifullin, R.; Eren, H.; Ulusoy, T. G.; Okyay, Ali Kemal; Bıyıklı, Necmi; Güler, Mustafa O. (Wiley - V C H Verlag GmbH & Co. KGaA, 2016)
        Here peptide amphiphile (PA) nanofiber network is exploited as a three‐dimensional soft template to construct anatase TiO2 and wurtzite ZnO nanonetworks. Atomic layer deposition (ALD) technique is used to coat the organic ...
      • Thumbnail

        Facile Synthesis of Three-Dimensional Pt-TiO2Nano-networks: A Highly Active Catalyst for the Hydrolytic Dehydrogenation of Ammonia–Borane 

        Khalily, M. A.; Eren, H.; Akbayrak, S.; Susapto, H. H.; Bıyıklı, Necmi; Özkar, S.; Güler, Mustafa O. (Wiley, 2016)
        Three‐dimensional (3D) porous metal and metal oxide nanostructures have received considerable interest because organization of inorganic materials into 3D nanomaterials holds extraordinary properties such as low density, ...
      • Thumbnail

        Atomic layer deposition of metal oxides on self-assembled peptide nanofiber templates for fabrication of functional nanomaterials 

        Eren, Hamit (Bilkent University, 2016-08)
        There are mainly two basic approaches in nanostructured materials synthesis. The rst one is the top-down approach and requires material removal from a bulk substrate material by chemical, physical, mechanical or thermal ...

      Browse

      All of BUIRCommunities & CollectionsTitlesAuthorsAdvisorsBy Issue DateKeywordsTypeDepartmentsCoursesThis CollectionTitlesAuthorsAdvisorsBy Issue DateKeywordsTypeDepartmentsCourses

      My Account

      Login

      Statistics

      View Usage StatisticsView Google Analytics Statistics

      Bilkent University

      If you have trouble accessing this page and need to request an alternate format, contact the User and Access Services. Phone: (312) 290 1298
      © Bilkent University - Library IT

      Contact Us | Send Feedback | Off-Campus Access | Admin | Privacy