Manipulation of particles using inertial microfluidics and viscoelastic fluids
Author
Asghari, Mohammad
Advisor
Elbüken, Çağlar
Date
2018-03Publisher
Bilkent University
Language
English
Type
ThesisItem Usage Stats
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Abstract
Recent years have witnessed an elevated trend in using miniaturized and labon-
a-chip systems in biomedical devices due to numerous advantages including
minimal sample/reagent consumption, portability, and superior performance.
One of the key challenges within these microsystems is to precisely manipulate
and order bio-particles. Various techniques have been introduced to accomplish
this mission. Inertial microfluidics enables lateral migration of particles and cells
in laminar flow regime due to the velocity gradient effect in moderate Reynolds
number. Moreover, viscoelastic
fluids exploit intrinsic elastic property of the fluids
to transfer particles and cells across laminar
ow streamlines. Both methods
utilize inherent properties of fluids alleviating any external force field inducer.
This dissertation elucidates inertial and viscoelastic effects on particles and cells
motion and investigates some unexplored migration behaviors. For inertial migration
study, a new fabrication method termed tape'n roll is introduced enabling
to study migration in both 2D and 3D structures. To better unravel the covert
mechanism of migration, computational model is applied. For viscoelastic behavior
study, focusing of particles inside three different viscoelastic fluids in a straight
glass capillary tube is scrutinized through optical system and image processing.