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dc.contributor.advisorTekinay, Ayşe Begüm
dc.contributor.authorYılmaz, Canelif
dc.date.accessioned2017-08-07T06:38:02Z
dc.date.available2017-08-07T06:38:02Z
dc.date.copyright2017-07
dc.date.issued2017-07
dc.date.submitted2017-08-04
dc.identifier.urihttp://hdl.handle.net/11693/33531
dc.descriptionCataloged from PDF version of article.en_US
dc.descriptionThesis (M.S.): Bilkent University, Department of Neuroscience, İhsan Doğramacı Bilkent University, 2017.en_US
dc.descriptionIncludes bibliographical references (leaves 63-72).en_US
dc.description.abstractPeripheral nerve regeneration is a tightly regulated process that entails the degeneration, proliferation, alignment and remyelination of Schwann cells. Tuning the bioactivity is important to support all of these processes and achieving successful regeneration. Extracellular matrix (ECM) proteins are important molecules for controlling cell behavior and differentiation. Mimicking the natural ECM proteins is a promising approach for promoting regeneration in peripheral nerve injury. In this study, we investigated the biocompatibility and bioactivity of two natural ECM mimicking peptide amphiphile (PA) molecules, heparan sulfate-mimicking PA (HM-PA) and laminin-mimicking PA (LN-PA), and showed that they self-assemble into ECM-like nanofibrous networks. These bioactive nanofibers promote the viability, proliferation and spreading of Schwann cells, and that the combination of the two bioactive epitopes supports both early and late neuroregenerative responses of Schwann cells. We have also shown that these nanofibers support the attachment and neurite extension of dorsal root ganglion neurons, and promotes neurite alignment and assembly in DRG-Schwann cell co-cultures.en_US
dc.description.statementofresponsibilityby Canelif Yılmaz.en_US
dc.format.extentxvi, 72 leaves : illustrations (some color), charts ; 29 cmen_US
dc.language.isoEnglishen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPeptidesen_US
dc.subjectPeptide nanofibersen_US
dc.subjectBiomimetic materialsen_US
dc.subjectPeripheral nerve injuryen_US
dc.subjectNerve regenerationen_US
dc.subjectSchwann cellsen_US
dc.subjectDRGen_US
dc.titleInvestigating the effects of bioactive peptide nanofibers on the growth and differentiation behaviour of nervous system cellsen_US
dc.title.alternativeBiyoaktif peptit nanofiberlerin sinir sistemi hücrelerinin büyüme ve farklılaşma davranışları üzerındeki etkilerinin incelenmesien_US
dc.typeThesisen_US
dc.departmentGraduate Program in Neuroscienceen_US
dc.publisherBilkent Universityen_US
dc.description.degreeM.S.en_US
dc.identifier.itemidB156080
dc.embargo.release2019-07-26


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