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      • Theses - Graduate Program in Neuroscience
      • Graduate Program in Neuroscience - Master's degree
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      Investigating the effects of bioactive peptide nanofibers on the growth and differentiation behaviour of nervous system cells

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      Embargo Lift Date: 2019-07-26
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      Author
      Yılmaz, Canelif
      Advisor
      Tekinay, Ayşe Begüm
      Date
      2017-08
      Publisher
      Bilkent University
      Language
      English
      Type
      Thesis
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      Abstract
      Peripheral nerve regeneration is a tightly regulated process that entails the degeneration, proliferation, alignment and remyelination of Schwann cells. Tuning the bioactivity is important to support all of these processes and achieving successful regeneration. Extracellular matrix (ECM) proteins are important molecules for controlling cell behavior and differentiation. Mimicking the natural ECM proteins is a promising approach for promoting regeneration in peripheral nerve injury. In this study, we investigated the biocompatibility and bioactivity of two natural ECM mimicking peptide amphiphile (PA) molecules, heparan sulfate-mimicking PA (HM-PA) and laminin-mimicking PA (LN-PA), and showed that they self-assemble into ECM-like nanofibrous networks. These bioactive nanofibers promote the viability, proliferation and spreading of Schwann cells, and that the combination of the two bioactive epitopes supports both early and late neuroregenerative responses of Schwann cells. We have also shown that these nanofibers support the attachment and neurite extension of dorsal root ganglion neurons, and promotes neurite alignment and assembly in DRG-Schwann cell co-cultures.
      Keywords
      Peptides
      Peptide nanofibers
      Biomimetic materials
      Peripheral nerve injury
      Nerve regeneration
      Schwann cells
      DRG
      Permalink
      http://hdl.handle.net/11693/33531
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      • Graduate Program in Neuroscience - Master's degree 37
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