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dc.contributor.advisorOrtaç, Bülenden_US
dc.contributor.authorTören, Pelinen_US
dc.date.accessioned2017-01-02T10:25:17Z
dc.date.available2017-01-02T10:25:17Z
dc.date.copyright2016-11
dc.date.issued2016-11
dc.date.submitted2016-12-22
dc.identifier.urihttp://hdl.handle.net/11693/32600
dc.descriptionCataloged from PDF version of article.en_US
dc.descriptionThesis (Ph.D.): Bilkent University, Department of Materials Science and Nanotechnology, İhsan Doğramacı Bilkent University, 2016.en_US
dc.descriptionIncludes bibliographical references (leaves 109-134).en_US
dc.description.abstractWhispering - Gallery - Mode type microresonators provide great opportunities for label - free biosensing, allowing detections down to single - molecule levels. Microtoroids as optical resonators are quite sensitive and preferable biosensors due to their high quality factors. However, their surface design should be carefully considered for a selective biodetection. For this purpose, studies on WGM type biosensing for DNA, RNA and protein detections using various surface modifications are herein summarized. Over and above, this thesis mainly focuses on the microfabrication and surface modification of the microtoroids for various selective biosensing purposes such as antigen detection in complex media or detecting single base pair DNA alterations in buffer. With this regard, the developed microtoroid surface modification for dual characteristics (anti - fouling property and bioconjugability) is described in detail. The dual surface approach, used for selective Interleukin - 2 and Exotoxin - A detections in complex media, is applied to the microtoroids. Biosensing in complex media is a challeging task to perform unless the calibration approach is used. To overcome this challenge the suggested surface modification approach for nano - molar level detections is explained in detail. Besides, a novel surface modification approach for a selective single - stranded DNA detection based on discriminating single base pairs is portrayed as well.en_US
dc.description.statementofresponsibilityby Pelin Tören.en_US
dc.format.extentxxi, 141 pages : charts.en_US
dc.language.isoEnglishen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectOptical Resonatoren_US
dc.subjectMicrotoroiden_US
dc.subjectUltra - high Qen_US
dc.subjectWhispering - Gallery - Modeen_US
dc.subjectLabel - freeen_US
dc.subjectBiosensingen_US
dc.titleUltra high quality factor microtoroidal optical resonators in label - free biosensing applications with high sensitivity and selectivityen_US
dc.title.alternativeÇok yüksek kalite faktörlü mikrotoroidal optik rezonatörler ile yüksel hassasiyet ve seçicilikte etiketsiz biyolojik algılama uygulamalarıen_US
dc.typeThesisen_US
dc.departmentGraduate Program in Materials Science and Nanotechnologyen_US
dc.publisherBilkent Universityen_US
dc.description.degreePh.D.en_US
dc.identifier.itemidB154948
dc.embargo.release2017-11-01


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