dc.contributor.advisor | Ortaç, Bülend | |
dc.contributor.author | Tören, Pelin | |
dc.date.accessioned | 2017-01-02T10:25:17Z | |
dc.date.available | 2017-01-02T10:25:17Z | |
dc.date.copyright | 2016-11 | |
dc.date.issued | 2016-11 | |
dc.date.submitted | 2016-12-22 | |
dc.identifier.uri | http://hdl.handle.net/11693/32600 | |
dc.description | Cataloged from PDF version of article. | en_US |
dc.description | Thesis (Ph.D.): Bilkent University, Department of Materials Science and Nanotechnology, İhsan Doğramacı Bilkent University, 2016. | en_US |
dc.description | Includes bibliographical references (leaves 109-134). | en_US |
dc.description.abstract | Whispering - Gallery - Mode type microresonators provide great opportunities for
label - free biosensing, allowing detections down to single - molecule levels. Microtoroids
as optical resonators are quite sensitive and preferable biosensors due
to their high quality factors. However, their surface design should be carefully
considered for a selective biodetection. For this purpose, studies on WGM type
biosensing for DNA, RNA and protein detections using various surface modifications
are herein summarized. Over and above, this thesis mainly focuses on the
microfabrication and surface modification of the microtoroids for various selective
biosensing purposes such as antigen detection in complex media or detecting
single base pair DNA alterations in buffer. With this regard, the developed microtoroid
surface modification for dual characteristics (anti - fouling property and
bioconjugability) is described in detail. The dual surface approach, used for selective
Interleukin - 2 and Exotoxin - A detections in complex media, is applied
to the microtoroids. Biosensing in complex media is a challeging task to perform
unless the calibration approach is used. To overcome this challenge the suggested
surface modification approach for nano - molar level detections is explained in
detail. Besides, a novel surface modification approach for a selective single -
stranded DNA detection based on discriminating single base pairs is portrayed
as well. | en_US |
dc.description.statementofresponsibility | by Pelin Tören. | en_US |
dc.format.extent | xxi, 141 pages : charts. | en_US |
dc.language.iso | English | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Optical Resonator | en_US |
dc.subject | Microtoroid | en_US |
dc.subject | Ultra - high Q | en_US |
dc.subject | Whispering - Gallery - Mode | en_US |
dc.subject | Label - free | en_US |
dc.subject | Biosensing | en_US |
dc.title | Ultra high quality factor microtoroidal optical resonators in label - free biosensing applications with high sensitivity and selectivity | en_US |
dc.title.alternative | Çok yüksek kalite faktörlü mikrotoroidal optik rezonatörler ile yüksel hassasiyet ve seçicilikte etiketsiz biyolojik algılama uygulamaları | en_US |
dc.type | Thesis | en_US |
dc.department | Graduate Program in Materials Science and Nanotechnology | en_US |
dc.publisher | Bilkent University | en_US |
dc.description.degree | Ph.D. | en_US |
dc.identifier.itemid | B154948 | |
dc.embargo.release | 2017-11-01 | |