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      • Graduate Program in Materials Science and Nanotechnology - Ph.D. / Sc.D.
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      • Theses - Graduate Program in Materials Science and Nanotechnology
      • Graduate Program in Materials Science and Nanotechnology - Ph.D. / Sc.D.
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      Novel miniaturized sensors for on-site biological and chemical detection

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      Embargo Lift Date: 2018-08-17
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      Author
      Güner, Hasan
      Advisor
      Dana, Aykutlu
      Date
      2016-08
      Publisher
      Bilkent University
      Language
      English
      Type
      Thesis
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      Abstract
      The development of miniaturized analytical systems brought several examples of novel platforms for a variety of applications in medical diagnostics, food safety, biodefense, agricultural and environmental monitoring. Portability, sensitivity, reliability, short turn-around-time, cost-effciency and connectivity are some of the critical assets that successful devices should possess. The advancements in such areas enabled the detection and analysis of biological and chemical agents outside the laboratory settings. In this thesis, we focus on the development of miniaturized sensor designs for on-site biological and chemical detection utilizing surface plasmon resonance sensing and infrared absorption spectroscopy. We proposed an integrated refractometric sensor combining a grating-coupled plasmon resonance surface with a planar photodiode which can find applications in lab-on-a-chip designs with high integration density. In order to address the use of lab-on-a-chip systems in point-of-care testing applications, we have developed a surface plasmon resonance imaging platform integrated with a smartphone. We have fabricated low cost and sensitive grating coupled surface plasmon resonance sensor chips using of-the-shelf optical storage discs. Then we have experimentally shown the capability of multiplexed detection and biomolecular sensing. Finally, we demonstrated infrared absorption spectroscopy on a mobile phone by developing a compact mid-infrared spectrometer that hosts a miniature uncooled thermal camera and a custom-designed silicon transmission diffraction grating.
      Keywords
      Miniature sensors
      Analytical systems
      Lab-on-a-chip devices
      Surface plasmon resonance sensing
      Infrared absorption spectroscopy
      Mobile phone based sensing
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      http://hdl.handle.net/11693/32208
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      • Graduate Program in Materials Science and Nanotechnology - Ph.D. / Sc.D. 73
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