Self-assembled peptide based biomaterials for drug delivery and regenerative medicine
Author
Çinar, Göksu
Advisor
Güler, Mustafa Özgür
Date
2016-06Publisher
Bilkent University
Language
English
Type
ThesisItem Usage Stats
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Abstract
Self-assembly is a nature inspired novel engineering tool to build functional new
generation of adaptable and complex biomaterials with variety of chemical and
physical properties based on recent discoveries at the interface of chemistry, biology
and materials science. Within self-assembling building blocks, peptides consisting
natural amino acids and possibilities to integrate other molecules via synthetic
approaches are intriguing biomacromolecules to obtain dynamic architectures at both
nano and bulk scales for biomedical applications. In this thesis, the development of
novel biomaterials through molecular self-assembly of the biomimetic peptides,
bioactive peptide amphiphiles and their composite architectures with polymeric
system for biomedical applications were presented. In the first chapter, the concept of
self-assembly, design principles of the self-assembling peptide based building blocks
and advanced characterization techniques for these materials were discussed to provide
general perspective on the field. The applications of peptide based biomaterials with
an emphasis on the drug delivery and regenerative medicine purposes were also
highlighted in this part. In the second chapter, amyloid inspired self-assembling peptides and their supramolecular assemblies were presented in the context of
developing nature-inspired biocompatible and mechanically stable supramolecular
peptide based biomaterials. In the third chapter, supramolecular PA nanofiber gels
which can form supramolecular nanofibrous networks at physiological conditions and
encapsulate chemotherapeutics with high efficacy were examined as controlled local
drug delivery system at both in vitro and in vivo conditions. In the fourth chapter, the
facile fabrication strategy to create a novel self-assembled peptide amphiphile (PA)
nanofibers and PEG composite hydrogel system as synthetic ECM analogues was
discussed. It was showed that the synergistic combination of different classes of
materials provide us new opportunities to develop biomaterials with independently
tunable biochemical, mechanical and physical properties.
Keywords
Self-assemblyBiomaterials
Amyloid inspired peptides
Peptide amphiphiles
Nanofibers
Supramolecular nanofiber gels
Drug delivery
Controlled drug release and regenerative medicine