dc.contributor.advisor | Öztürk, Mehmet | |
dc.contributor.author | Sever, Nurettin İlter | |
dc.date.accessioned | 2016-07-01T10:57:59Z | |
dc.date.available | 2016-07-01T10:57:59Z | |
dc.date.issued | 2003 | |
dc.identifier.uri | http://hdl.handle.net/11693/29330 | |
dc.description | Cataloged from PDF version of article. | en_US |
dc.description.abstract | Breast cancer is the most common type of cancer and the second leading cause of
cancer deaths among women. Most of breast carcinoma arises from the breast ductal
epithelium. Recent studies in the past decade have displayed that many organs in our
body possess organ-specific stem cells which have the capacity of self-renewal and
differentiation toward specialized cell types which are specific for that organ. Breast
is also one of these organs and breast epithelium contains stem/progenitor cells
which give rise to two types of differentiated breast epithelial cell types: luminal
epithelial and myoepithelial. Due to their property of division-competence for selfrenewal,
stem cells are more prone to malignant transformation than more
differentiated cell types. Therefore, it is considered that breast cancer may have
arisen from a stem/progenitor cell found in mammary epithelium and recent studies
support this hypothesis. In the study described in this thesis, breast cancer cell lines
have been demonstrated to display stem/progenitor cell-like protein expression.
Breast cancer cell lines have been characterized according to their marker protein
expression related to the differentiation status of the mammary epithelial cell type by
using immunofluorescence and Western blotting techniques. Also, single cellcloning
of GI-101 cell line has been performed. It has been demonstrated that a
single cell could give rise to different cell populations, further supporting the
hypothesis that breast cancer cell lines display stem/progenitor cell-like protein
expression. | en_US |
dc.description.statementofresponsibility | Sever, Nurettin İlter | en_US |
dc.format.extent | xi, 70 leaves, illustrations, tables, graphs, 30 cm | en_US |
dc.language.iso | English | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject.lcc | WP870 .S484 2003 | en_US |
dc.subject.lcsh | Breast Cancer. | en_US |
dc.title | Stem cell-like protein expression in breast cancer cell lines | en_US |
dc.type | Thesis | en_US |
dc.department | Department of Moleculer Biology | en_US |
dc.publisher | Bilkent University | en_US |
dc.description.degree | M.S. | en_US |
dc.identifier.itemid | BILKUTUPB071894 | |