|dc.description.abstract||Cellular processes form the hardware layer of living organisms. Malfunctions in
cellular processes are responsible for most of the currently incurable diseases. Not
surprisingly, knowledge about cellular processes are growing at an enormous rate.
However, today’s molecular biology suffers from lack of a formal representation
system for cellular processes. Most of the knowledge is locked in literature, that
are not accessible to computational analysis and modeling. Given the complexity
of the system we are attacking, the need for a representation system and modeling
tools for cellular processes are clear.
In this dissertation, we describe an ontology for modeling processes. Our
ontology possesses several unique features, including ability to represent abstractions
and multiple levels of detail, cellular compartments and molecular states.
Furthermore, it was designed to meet several user and system requirements, including
ease of integration, querying, analysis and visualization.
Based on this ontology we also implemented a set of software tools within
the Patika project. Primary use cases of Patika are integration, querying and
visualization, and we have obtained satisfactory results proving the feasibility of
Compared with existing alternative methods of representing and querying information
about cellular processes, Patika provides several advantages, including
a regular representation system, powerful querying options, an advanced visualization.
Moreover Patika models can be analyzed by computational methods
such as flux analysis or pathway activity inference. Although it has a more steep
learning curve compared to existing ad hoc representation systems, we believe
that tools like Patika will be essential for molecular biology research in the