A novel fiber laser development for photoacoustic microscopy
Please cite this item using this persistent URLhttp://hdl.handle.net/11693/28013
Progress in Biomedical Optics and Imaging - Proceedings of SPIE
- Conference Paper 
Photoacoustic microscopy, as an imaging modality, has shown promising results in imaging angiogenesis and cutaneous malignancies like melanoma, revealing systemic diseases including diabetes, hypertension, tracing drug efficiency and assessment of therapy, monitoring healing processes such as wound cicatrization, brain imaging and mapping. Clinically, photoacoustic microscopy is emerging as a capable diagnostic tool. Parameters of lasers used in photoacoustic microscopy, particularly, pulse duration, energy, pulse repetition frequency, and pulse-to-pulse stability affect signal amplitude and quality, data acquisition speed and indirectly, spatial resolution. Lasers used in photoacoustic microscopy are typically Q-switched lasers, low-power laser diodes, and recently, fiber lasers. Significantly, the key parameters cannot be adjusted independently of each other, whereas microvasculature and cellular imaging, e.g., have different requirements. Here, we report an integrated fiber laser system producing nanosecond pulses, covering the spectrum from 600 nm to 1100 nm, developed specifically for photoacoustic excitation. The system comprises of Yb-doped fiber oscillator and amplifier, an acousto-optic modulator and a photonic-crystal fiber to generate supercontinuum. Complete control over the pulse train, including generation of non-uniform pulse trains, is achieved via the AOM through custom-developed field-programmable gate-array electronics. The system is unique in that all the important parameters are adjustable: pulse duration in the range of 1-3 ns, pulse energy up to 10 μJ, repetition rate from 50 kHz to 3 MHz. Different photocoustic imaging probes can be excited with the ultrabroad spectrum. The entire system is fiber-integrated; guided-beam-propagation rendersit misalignment free and largely immune to mechanical perturbations. The laser is robust, low-cost and built using readily available components. © 2013 Copyright SPIE.
Showing items related by title, author, creator and subject.
All-fiber low-noise high-power femtosecond Yb-fiber amplifier system seeded by an all-normal dispersion fiber oscillator Mukhopadhyay P.K.; Özgören, K.; Budunoilu I.L.; Ilday F.Ö. (2009)We report an all-fiber, high-power, low-noise amplifier system seeded by an all-normal-dispersion-mode-locked Yb-doped fiber laser oscillator. Up to 10.6 W of average power is obtained at a repetition rate of 43 MHz with ...
Lecaplain, C.; Ortac, B.; MacHinet G.; Boullet J.; Baumgartl, M.; Schreiber, T.; Cormier, E.; Hideur, A. (2011)Energy scaling of ultrafast Yb-doped fiber oscillators has experienced rapid progress largely driven by many applications that require high average power femtosecond pulses. The fundamental challenge for ultrafast fiber ...
Zhang, Z.; Popa, D.; Wittwer V.J.; Milana, S.; Hasan, T.; Jiang, Z.; Ferrari, A.C.; Ilday F.Ö. (American Institute of Physics Inc., 2015)We report dissipative soliton generation from an Yb-doped all-fiber nonlinearity- and dispersion-managed nanotube mode-locked laser. A simple all-fiber ring cavity exploits a photonic crystal fiber for both nonlinearity ...