A novel fiber laser development for photoacoustic microscopy
Author(s)
Date
2013Source Title
Proceedings of SPIE, Progress in Biomedical Optics and Imaging
Print ISSN
1605-7422
Publisher
SPIE
Volume
8581
Language
English
Type
Conference PaperItem Usage Stats
154
views
views
170
downloads
downloads
Abstract
Photoacoustic microscopy, as an imaging modality, has shown promising results in imaging angiogenesis and cutaneous malignancies like melanoma, revealing systemic diseases including diabetes, hypertension, tracing drug efficiency and assessment of therapy, monitoring healing processes such as wound cicatrization, brain imaging and mapping. Clinically, photoacoustic microscopy is emerging as a capable diagnostic tool. Parameters of lasers used in photoacoustic microscopy, particularly, pulse duration, energy, pulse repetition frequency, and pulse-to-pulse stability affect signal amplitude and quality, data acquisition speed and indirectly, spatial resolution. Lasers used in photoacoustic microscopy are typically Q-switched lasers, low-power laser diodes, and recently, fiber lasers. Significantly, the key parameters cannot be adjusted independently of each other, whereas microvasculature and cellular imaging, e.g., have different requirements. Here, we report an integrated fiber laser system producing nanosecond pulses, covering the spectrum from 600 nm to 1100 nm, developed specifically for photoacoustic excitation. The system comprises of Yb-doped fiber oscillator and amplifier, an acousto-optic modulator and a photonic-crystal fiber to generate supercontinuum. Complete control over the pulse train, including generation of non-uniform pulse trains, is achieved via the AOM through custom-developed field-programmable gate-array electronics. The system is unique in that all the important parameters are adjustable: pulse duration in the range of 1-3 ns, pulse energy up to 10 μJ, repetition rate from 50 kHz to 3 MHz. Different photocoustic imaging probes can be excited with the ultrabroad spectrum. The entire system is fiber-integrated; guided-beam-propagation rendersit misalignment free and largely immune to mechanical perturbations. The laser is robust, low-cost and built using readily available components. © 2013 Copyright SPIE.
Keywords
Acousto-optic modulatorData acquisition speed
Mechanical perturbations
Mode-locked
Photo-acoustic imaging
Photoacoustic excitation
Pulse repetition frequencies
Super continuum
Disease control
Drug therapy
Fiber lasers
Mode-locked fiber lasers
Photoacoustic effect
Photomasks
Photonic crystal fibers
Photons
Q switched lasers
Ultrasonics
Photoacoustic microscopy
Permalink
http://hdl.handle.net/11693/28013Published Version (Please cite this version)
http://dx.doi.org/10.1117/12.2004910Collections
Related items
Showing items related by title, author, creator and subject.
-
All-fiber nanosecond laser system generating supercontinuum spectrum for photoacoustic imaging
Yavas, S.; Kipergil, E. A.; Akçaalan, Önder; Eldeniz, Y. Burak; Arabul, U.; Erkol H.; Unlu, M.B.; Ilday, F. Ömer (IEEE, 2013)Photoacoustic microscopy (PAM) research, as an imaging modality, has shown promising results in imaging angiogenesis and cutaneous malignancies like melanoma, revealing systemic diseases including diabetes, hypertension, ... -
Effect of solvent refractive index on the surface plasmon resonance nanoparticle optical absorption
Ertas, G.; Süzer, Şefik (2007)Optical properties of plasmon coupled silver and gold nanoparticles were studied as a function of the refractive index of the surrounding medium. Our studies confirmed that the effect of changes in the refractive index of ... -
Development of a fiber laser with independently adjustable properties for optical resolution photoacoustic microscopy
Aytac-Kipergil, E.; Demirkiran, A.; Uluc, N.; Yavas, S.; Kayikcioglu, T.; Salman, S.; Karamuk, S. G.; Ilday, F. O.; Unlu, M.B. (Nature Publishing Group, 2016)Photoacoustic imaging is based on the detection of generated acoustic waves through thermal expansion of tissue illuminated by short laser pulses. Fiber lasers as an excitation source for photoacoustic imaging have recently ...