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      A novel fiber laser development for photoacoustic microscopy

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      Author(s)
      Yavaş, Seydi
      Aytac-Kipergil, E.
      Arabul, M.U.
      Erkol H.
      Akçaalan, Önder
      Eldeniz, Y.B.
      İlday, F. Ömer
      Unlu, M.B.
      Date
      2013
      Source Title
      Proceedings of SPIE, Progress in Biomedical Optics and Imaging
      Print ISSN
      1605-7422
      Publisher
      SPIE
      Volume
      8581
      Language
      English
      Type
      Conference Paper
      Item Usage Stats
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      170
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      Abstract
      Photoacoustic microscopy, as an imaging modality, has shown promising results in imaging angiogenesis and cutaneous malignancies like melanoma, revealing systemic diseases including diabetes, hypertension, tracing drug efficiency and assessment of therapy, monitoring healing processes such as wound cicatrization, brain imaging and mapping. Clinically, photoacoustic microscopy is emerging as a capable diagnostic tool. Parameters of lasers used in photoacoustic microscopy, particularly, pulse duration, energy, pulse repetition frequency, and pulse-to-pulse stability affect signal amplitude and quality, data acquisition speed and indirectly, spatial resolution. Lasers used in photoacoustic microscopy are typically Q-switched lasers, low-power laser diodes, and recently, fiber lasers. Significantly, the key parameters cannot be adjusted independently of each other, whereas microvasculature and cellular imaging, e.g., have different requirements. Here, we report an integrated fiber laser system producing nanosecond pulses, covering the spectrum from 600 nm to 1100 nm, developed specifically for photoacoustic excitation. The system comprises of Yb-doped fiber oscillator and amplifier, an acousto-optic modulator and a photonic-crystal fiber to generate supercontinuum. Complete control over the pulse train, including generation of non-uniform pulse trains, is achieved via the AOM through custom-developed field-programmable gate-array electronics. The system is unique in that all the important parameters are adjustable: pulse duration in the range of 1-3 ns, pulse energy up to 10 μJ, repetition rate from 50 kHz to 3 MHz. Different photocoustic imaging probes can be excited with the ultrabroad spectrum. The entire system is fiber-integrated; guided-beam-propagation rendersit misalignment free and largely immune to mechanical perturbations. The laser is robust, low-cost and built using readily available components. © 2013 Copyright SPIE.
      Keywords
      Acousto-optic modulator
      Data acquisition speed
      Mechanical perturbations
      Mode-locked
      Photo-acoustic imaging
      Photoacoustic excitation
      Pulse repetition frequencies
      Super continuum
      Disease control
      Drug therapy
      Fiber lasers
      Mode-locked fiber lasers
      Photoacoustic effect
      Photomasks
      Photonic crystal fibers
      Photons
      Q switched lasers
      Ultrasonics
      Photoacoustic microscopy
      Permalink
      http://hdl.handle.net/11693/28013
      Published Version (Please cite this version)
      http://dx.doi.org/10.1117/12.2004910
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      • Department of Physics 2397
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