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      Microfluidic device for synthesis of chitosan nanoparticles

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      Author
      Çetin, Barbaros
      Taze, Serdar
      Asik, M.D.
      Tuncel, S.A.
      Date
      2013
      Source Title
      Proceedings of the ASME 2013 Fluids Engineering Division Summer Meeting
      Print ISSN
      0888-8116
      Publisher
      ASME
      Volume
      2
      Language
      English
      Type
      Conference Paper
      Item Usage Stats
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      Abstract
      Chitosan nanoparticles have a biodegradable, biocompatible, non-toxic structure, and commonly used for drug delivery systems. In this paper, simulation of a microfluidic device for the synthesis of chitosan nanoparticle is presented. The flow filed together with the concentration field within the microchannel network is simulated using COMSOL Multiphysics® simulation environment. Different microchannel geometries are analyzed, and the mixing performance of these configurations are compared. As a result, a 3D design for a microfluidics platform which includes four channel each of which performs the synthesis in parallel is proposed. Future research directions regarding the fabrication of the microfluidic device and experimentation phase are addressed and discussed. Copyright © 2013 by ASME.
      Keywords
      Chitosan nanoparticles
      Concentration fields
      Drug delivery system
      Future research directions
      Micro-fluidic devices
      Microchannel geometries
      Microchannel network
      Simulation environment
      Biocompatibility
      Drug delivery
      Fluidic devices
      Microfluidics
      Multiphase flow
      Nanoparticles
      Chitosan
      Permalink
      http://hdl.handle.net/11693/27930
      Published Version (Please cite this version)
      http://dx.doi.org/10.1115/FEDSM2013-16349
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      • Department of Mechanical Engineering 278
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