Microfluidic device for synthesis of chitosan nanoparticles
Author
Çetin, Barbaros
Taze, Serdar
Asik, M.D.
Tuncel, S.A.
Date
2013Source Title
Proceedings of the ASME 2013 Fluids Engineering Division Summer Meeting
Print ISSN
0888-8116
Publisher
ASME
Volume
2
Language
English
Type
Conference PaperItem Usage Stats
151
views
views
184
downloads
downloads
Abstract
Chitosan nanoparticles have a biodegradable, biocompatible, non-toxic structure, and commonly used for drug delivery systems. In this paper, simulation of a microfluidic device for the synthesis of chitosan nanoparticle is presented. The flow filed together with the concentration field within the microchannel network is simulated using COMSOL Multiphysics® simulation environment. Different microchannel geometries are analyzed, and the mixing performance of these configurations are compared. As a result, a 3D design for a microfluidics platform which includes four channel each of which performs the synthesis in parallel is proposed. Future research directions regarding the fabrication of the microfluidic device and experimentation phase are addressed and discussed. Copyright © 2013 by ASME.
Keywords
Chitosan nanoparticlesConcentration fields
Drug delivery system
Future research directions
Micro-fluidic devices
Microchannel geometries
Microchannel network
Simulation environment
Biocompatibility
Drug delivery
Fluidic devices
Microfluidics
Multiphase flow
Nanoparticles
Chitosan