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dc.contributor.authorOsmanagaoglu, O.en_US
dc.contributor.authorKiran, F.en_US
dc.contributor.authorYagci, F. C.en_US
dc.contributor.authorGursel, I.en_US
dc.date.accessioned2016-02-08T11:03:58Z
dc.date.available2016-02-08T11:03:58Z
dc.date.issued2013en_US
dc.identifier.issn1590-4261
dc.identifier.urihttp://hdl.handle.net/11693/26723
dc.description.abstractSome of the important properties of probiotics are the ability to survive during gastrointestinal transit and to modulate the immune functions. The objectives of the reported study were to assess in vivo gastrointestinal survival of orally administered Pediococcus pentosaceus OZF using an animal model BALB/c mice, and to examine its effects on the immune response. Following oral administration to mice, the ability of Pediococcus pentosaceus OZF to pass and survive through the mouse gastrointestinal system was investigated by analyzing the recovery of the strain in fecal samples. Microbiological and polymerase chain reaction (PCR) methods proved that the strain OZF could overcome specific conditions in the gastrointestinal tract of mice and reach the intestine alive after ingestion. To observe the effect of oral administration on immune response, IL-6, IL-12 and IFN-γ were measured by ELISA, and the strain OZF was found to cause increases in IL-6 synthesis in regularly fed mice. However, stimulation was carried out with various concentrations of bacterial ssDNA and heat killed cells of Pediococcus pentosaceus OZF. The heat killed cells of the strain OZF were shown to produce IFN- γ independently from IL-12. On the other hand, a significant difference between control and experimental group was noticed when lipopolysaccharide, a TLR4 (toll like receptor) ligand, was used. Overall, Pediococcus pentosaceus OZF may be a valuable probiotic strain for therapeutic uses. Nevertheless, further studies on the mechanisms of immunomodulatory effect will allow for better clarification of the immune functions of this strain. © Springer-Verlag Berlin Heidelberg and the University of Milan 2012.en_US
dc.language.isoEnglishen_US
dc.source.titleAnnals of Microbiologyen_US
dc.relation.isversionofhttp://dx.doi.org/10.1007/s13213-012-0590-9en_US
dc.subjectProbioticen_US
dc.subjectSurvivalen_US
dc.subjectImmunomodulationen_US
dc.subjectIn vivoen_US
dc.subjectPediococcus pentosaceusen_US
dc.titleImmunomodulatory function and in vivo properties of pediococcus pentosaceus OZF, a promising probiotic strainen_US
dc.typeArticleen_US
dc.departmentDepartment of Molecular Biology and Genetics
dc.citation.spage1311en_US
dc.citation.epage1318en_US
dc.citation.volumeNumber63en_US
dc.citation.issueNumber4en_US
dc.identifier.doi10.1007/s13213-012-0590-9en_US
dc.publisherSpringeren_US


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