Synthesis and cytotoxicity studies of novel benzhydrylpiperazine carboxamide and thioamide derivatives
Date
2014
Authors
Gurdal, E. E.
Durmaz, I.
Cetin Atalay, R.
Yarim, M.
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Abstract
Synthesis and cytotoxic activities of 32 benzhydrylpiperazine derivatives with carboxamide and thioamide moieties were reported. In vitro cytotoxic activities of compounds were screened against hepatocellular (HUH-7), breast (MCF-7) and colorectal (HCT-116) cancer cell lines by sulphorhodamine B assay. In general, 4-chlorobenzhydrylpiperazine derivatives were more cytotoxic than other compounds. In addition, thioamide derivatives (6a-g) have higher growth inhibition than their carboxamide analogs. © 2014 Informa UK Ltd. All rights reserved.
Source Title
Journal of Enzyme Inhibition and Medicinal Chemistry
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Informa Healthcare
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Language
English