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dc.contributor.authorGezici, Ö.en_US
dc.contributor.authorDurmaz, I.en_US
dc.contributor.authorGüven, E. B.en_US
dc.contributor.authorÜnal, Ö.en_US
dc.contributor.authorÖzgün, A.en_US
dc.contributor.authorCetin Atalay, R.en_US
dc.contributor.authorTuncel, D.en_US
dc.date.accessioned2016-02-08T11:02:38Z
dc.date.available2016-02-08T11:02:38Z
dc.date.issued2014en_US
dc.identifier.issn2046-2069
dc.identifier.urihttp://hdl.handle.net/11693/26633
dc.description.abstractMultifunctional nanoparticles based on a green emitting, hydrophobic conjugated polymer, poly[(9,9-bis{propeny}fluorenyl-2,7-diyl)-co-(1,4-benzo-{2,1,3}-thiodiazole)] (PPFBT), that acts both as a fluorescent reporter and a matrix to accommodate an anti-cancer compound, camptothecin (CPT), were prepared, characterized and their potential as a fluorescent probe for cell imaging and as a drug delivery vehicle were evaluated via in vitro cell assays. The cell viability of human hepatocellular carcinoma cell line (Huh7) was investigated in the absence and presence of CPT with sulforhodamine B (SRB) and real-time cell electronic sensing (RT-CES) cytotoxicity assays.en_US
dc.language.isoEnglishen_US
dc.source.titleRSC Advancesen_US
dc.relation.isversionofhttp://dx.doi.org/10.1039/c3ra45120hen_US
dc.subjectCamptothecin (CPT)en_US
dc.subjectCytotoxicity assaysen_US
dc.subjectDrug delivery vehiclesen_US
dc.subjectFluorescent reporteren_US
dc.subjectHepatocellular carcinoma cellen_US
dc.subjectMulti-functional nanoparticlesen_US
dc.subjectPolymer nanoparticlesen_US
dc.subjectReal-time cell electronic sensingen_US
dc.subjectDrug deliveryen_US
dc.subjectCell cultureen_US
dc.titleDual functionality of conjugated polymer nanoparticles as an anticancer drug carrier and a fluorescent probe for cell imagingen_US
dc.typeArticleen_US
dc.departmentDepartment of Chemistryen_US
dc.departmentDepartment of Molecular Biology and Geneticsen_US
dc.departmentInstitute of Materials Science and Nanotechnology (UNAM)en_US
dc.citation.spage1302en_US
dc.citation.epage1309en_US
dc.citation.volumeNumber4en_US
dc.citation.issueNumber3en_US
dc.identifier.doi10.1039/c3ra45120hen_US
dc.publisherRoyal Society of Chemistryen_US


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