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      Dual functionality of conjugated polymer nanoparticles as an anticancer drug carrier and a fluorescent probe for cell imaging

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      Author
      Gezici, Ö.
      Durmaz, I.
      Güven, E. B.
      Ünal, Ö.
      Özgün, A.
      Cetin Atalay, R.
      Tuncel, D.
      Date
      2014
      Source Title
      RSC Advances
      Print ISSN
      2046-2069
      Publisher
      Royal Society of Chemistry
      Volume
      4
      Issue
      3
      Pages
      1302 - 1309
      Language
      English
      Type
      Article
      Item Usage Stats
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      Abstract
      Multifunctional nanoparticles based on a green emitting, hydrophobic conjugated polymer, poly[(9,9-bis{propeny}fluorenyl-2,7-diyl)-co-(1,4-benzo-{2,1,3}-thiodiazole)] (PPFBT), that acts both as a fluorescent reporter and a matrix to accommodate an anti-cancer compound, camptothecin (CPT), were prepared, characterized and their potential as a fluorescent probe for cell imaging and as a drug delivery vehicle were evaluated via in vitro cell assays. The cell viability of human hepatocellular carcinoma cell line (Huh7) was investigated in the absence and presence of CPT with sulforhodamine B (SRB) and real-time cell electronic sensing (RT-CES) cytotoxicity assays.
      Keywords
      Camptothecin (CPT)
      Cytotoxicity assays
      Drug delivery vehicles
      Fluorescent reporter
      Hepatocellular carcinoma cell
      Multi-functional nanoparticles
      Polymer nanoparticles
      Real-time cell electronic sensing
      Drug delivery
      Cell culture
      Permalink
      http://hdl.handle.net/11693/26633
      Published Version (Please cite this version)
      http://dx.doi.org/10.1039/c3ra45120h
      Collections
      • Department of Chemistry 631
      • Department of Molecular Biology and Genetics 452
      • Institute of Materials Science and Nanotechnology (UNAM) 1858
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