Patrolling monocytes control tumor metastasis to the lung
Hanna, R. N.
Thomas, G. D.
Biswas, S. K.
Hedrick, C. C.
American Association for the Advancement of Science
985 - 990
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The immune system plays an important role in regulating tumor growth and metastasis. Classical monocytes promote tumorigenesis and cancer metastasis, but how nonclassical "patrolling" monocytes (PMo) interact with tumors is unknown. Here we show that PMo are enriched in the microvasculature of the lung and reduce tumor metastasis to lung in multiple mouse metastatic tumor models. Nr4a1-deficient mice, which specifically lack PMo, showed increased lung metastasis in vivo. Transfer of Nr4a1-proficient PMo into Nr4a1-deficient mice prevented tumor invasion in the lung. PMo established early interactions with metastasizing tumor cells, scavenged tumor material from the lung vasculature, and promoted natural killer cell recruitment and activation. Thus, PMo contribute to cancer immunosurveillance and may be targets for cancer immunotherapy.
Cells and cell components
In vivo study
Natural killer cell
Mutant mouse strain
Nr4a1 protein, mouse
Nuclear receptor Nur77
Killer Cells, Natural
Mice, Mutant Strains
Nuclear Receptor Subfamily 4, Group A, Member 1
Published Version (Please cite this version)http://dx.doi.org/10.1126/science.aac9407
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