Patrolling monocytes control tumor metastasis to the lung
Hanna, R. N.
Thomas, G. D.
Biswas, S. K.
Hedrick, C. C.
American Association for the Advancement of Science
985 - 990
Item Usage Stats
MetadataShow full item record
The immune system plays an important role in regulating tumor growth and metastasis. Classical monocytes promote tumorigenesis and cancer metastasis, but how nonclassical "patrolling" monocytes (PMo) interact with tumors is unknown. Here we show that PMo are enriched in the microvasculature of the lung and reduce tumor metastasis to lung in multiple mouse metastatic tumor models. Nr4a1-deficient mice, which specifically lack PMo, showed increased lung metastasis in vivo. Transfer of Nr4a1-proficient PMo into Nr4a1-deficient mice prevented tumor invasion in the lung. PMo established early interactions with metastasizing tumor cells, scavenged tumor material from the lung vasculature, and promoted natural killer cell recruitment and activation. Thus, PMo contribute to cancer immunosurveillance and may be targets for cancer immunotherapy.
Cells and cell components
In vivo study
Natural killer cell
Mutant mouse strain
Nr4a1 protein, mouse
Nuclear receptor Nur77
Killer Cells, Natural
Mice, Mutant Strains
Nuclear Receptor Subfamily 4, Group A, Member 1
Published Version (Please cite this version)http://dx.doi.org/10.1126/science.aac9407
Showing items related by title, author, creator and subject.
Early outcomes after transoral CO2 laser resection of laryngeal and hypopharyngeal squamous cell carcinoma: One centre's experience Leong, S. C.; Kathan, C.; Mortimore, S. (Cambridge University Press, 2010)Objectives: To review early oncological outcomes following transoral CO2 laser resection of laryngeal and hypopharyngeal squamous cell carcinoma. Design: Retrospective review of hospital electronic database. Setting: Large ...
The miR-644a/CTBP1/p53 axis suppresses drug resistance by simultaneous inhibition of cell survival and epithelialmesenchymal transition in breast cancer Raza, U.; Saatci, O.; Uhlmann, S.; Ansari, S. A.; Eyüpoglu, E.; Yurdusev, E.; Mutlu, M.; Ersan, P. G.; Altundağ, M. K.; Zhang, J. D.; Dogan, H. T.; Güler, G.; Şahin, Ö. (Impact Journals LLC, 2016)Tumor cells develop drug resistance which leads to recurrence and distant metastasis. MicroRNAs are key regulators of tumor pathogenesis; however, little is known whether they can sensitize cells and block metastasis ...
Susil, R. C.; Krieger, A.; Derbyshire, J. A.; Tanacs, A.; Whitcomb, L. L.; Fichtinger, G.; Atalar, E. (Radiological Society of North America, Inc.Radiological Society of North America, Inc., 2003)The purpose of this study was to demonstrate the use of a transrectal system that enables precise magnetic resonance (MR) image guidance and monitoring of prostate interventions. The system used a closed-bore 1.5-T MR ...