Synthesis and characterization of amino acid conjugates of oleanolic acid and their in vitro cytotoxic effect on HCC cell lines
Author(s)
Date
2014Source Title
Pakistan Journal of Pharmaceutical Sciences
Print ISSN
1011-601X
Publisher
Pakistan Journal of Pharmaceutical Sciences
Volume
27
Issue
5
Pages
1491 - 1496
Language
English
Type
ArticleItem Usage Stats
290
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128
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Abstract
Oleanolic acid (3β-hydroxy-olean-12-en-28-oic acid; OA-01), a pentacyclic triterpene, exhibit a wide range of pharmacological and biological activities. We have isolated oleanolic acid from methanolic extract of Periploca aphylla, collected from surroundings of Karachi in the month of February. Furthermore, four known and two new C-28 amino acid conjugates of oleanolic acid were prepared to explore potential of these compounds on HCCs and one breast cancer cell line. Cytotoxic effects revealed that as compare to parent compound (OA-01), two derivatives OA-04 (p<0.0001) and OA-06 (p<0.01) showed significantly increased/higher inhibition rates.
Keywords
Oleanolic acidAmino acid
HCC cell lines
Amides
Periploca aphylla
Cell survival
Liver cell carcinoma
Breast tumor
Liver tumor