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      Synthesis and characterization of amino acid conjugates of oleanolic acid and their in vitro cytotoxic effect on HCC cell lines

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      Author(s)
      Mustufa, Muhammad Ayaz
      Hashmi, I. A.
      Manzoor, S.
      Ahmed, A.
      Ahmed, V.
      Aslam, A.
      Özen, Çiğdem
      Naqvi, N.
      Öztürk, Mehmet
      Ali, F. I.
      Date
      2014
      Source Title
      Pakistan Journal of Pharmaceutical Sciences
      Print ISSN
      1011-601X
      Publisher
      Pakistan Journal of Pharmaceutical Sciences
      Volume
      27
      Issue
      5
      Pages
      1491 - 1496
      Language
      English
      Type
      Article
      Item Usage Stats
      290
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      128
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      Abstract
      Oleanolic acid (3β-hydroxy-olean-12-en-28-oic acid; OA-01), a pentacyclic triterpene, exhibit a wide range of pharmacological and biological activities. We have isolated oleanolic acid from methanolic extract of Periploca aphylla, collected from surroundings of Karachi in the month of February. Furthermore, four known and two new C-28 amino acid conjugates of oleanolic acid were prepared to explore potential of these compounds on HCCs and one breast cancer cell line. Cytotoxic effects revealed that as compare to parent compound (OA-01), two derivatives OA-04 (p<0.0001) and OA-06 (p<0.01) showed significantly increased/higher inhibition rates.
      Keywords
      Oleanolic acid
      Amino acid
      HCC cell lines
      Amides
      Periploca aphylla
      Cell survival
      Liver cell carcinoma
      Breast tumor
      Liver tumor
      Permalink
      http://hdl.handle.net/11693/26392
      Collections
      • Department of Molecular Biology and Genetics 512
      • Genetics and Biotechnology Research Center (BİLGEN) 16
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